Document Detail


The effects of sex, metabolic syndrome and exercise on postprandial lipemia.
MedLine Citation:
PMID:  22974968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Exercise has been suggested to have cardioprotective benefits due to a lowering of postprandial triglycerides (PPTG). We hypothesized that a morning exercise bout would significantly lower PPTG measured over a full day, in response to moderate fat meals (35% energy) in men more so than women, and in metabolic syndrome (MetS) relative to normal weight (NW) individuals.
MATERIALS/METHODS: Participants completed two randomized study days; one control and one exercise day (60 min of morning exercise, 60% VO(2peak)). Meals were consumed at breakfast, lunch and dinner with the energy expended during exercise replaced on the active day. The areas (AUC) and incremental areas (IAUC) under the curve were calculated for total triglycerides, total cholesterol and other metabolites.
RESULTS: Exercise did not significantly change the PPTG AUC & IAUC overall, or within, or between, each sex or group (NW and MetS). Exercise induced a 30% decrease in total cholesterol IAUC (p=0.003) in NW subjects. Overall, women had a lower IAUC for PPTG compared to men (p=0.037), with the greatest difference between MetS women and MetS men, due to a sustained drop in TG after lunch in the women. This suggests that PP, rather than fasting, lipid analyses may be particularly important when evaluating sex differences in metabolic risk.
CONCLUSIONS: With energy replacement, moderate morning exercise did not result in a significant decrease in PPTG excursions. Exercise did elicit a significant decrease in PP cholesterol levels in NW subjects, suggesting a potential mechanism for the cardioprotective effects of exercise.
Authors:
Kimberly A Cox-York; Teresa A Sharp; Sarah A Stotz; Daniel H Bessesen; Michael J Pagliassotti; Tracy J Horton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-11
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  62     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-06-03     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adolescent
Adult
Area Under Curve
Blood Glucose / metabolism
Cholesterol / blood*
Cross-Over Studies
Exercise / physiology*
Fatty Acids, Nonesterified / blood
Female
Humans
Hyperlipidemias / blood,  metabolism*
Insulin / blood
Male
Metabolic Syndrome X / blood,  metabolism*
Postprandial Period
Sex Factors
Triglycerides / blood*
Young Adult
Grant Support
ID/Acronym/Agency:
DK071155/DK/NIDDK NIH HHS; M01 RR000051/RR/NCRR NIH HHS; MO1-RR000051/RR/NCRR NIH HHS; P30 DK048520/DK/NIDDK NIH HHS; P30-DK048520/DK/NIDDK NIH HHS; R01 DK071155/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Triglycerides; 97C5T2UQ7J/Cholesterol
Comments/Corrections

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