Document Detail

The effects of sevoflurane on isolated gravid human myometrium.
MedLine Citation:
PMID:  12413258     Owner:  NLM     Status:  MEDLINE    
The volatile anaesthetic agents are known to influence uterine muscle tone. All of the agents studied to date have been found to produce uterine relaxation. This property has been used to produce therapeutic uterine relaxation for difficult obstetric deliveries and the Ex Utero Intrapartum Treatment (EXIT) procedure. This study describes the effects of sevoflurane on isolated human myometrium at concentrations of 0.1, 0.25, 0.5, 0.75, 1.0, 1.5, 2.5 and 3.5 MAC. Sevoflurane produces dose-dependent depression of uterine muscle contractility with an ED50 of 0.94 MAC. Frequency of contraction was increased at concentrations of 2.5 MAC and greater. At concentrations of 3.5 MAC and above, uterine activity was virtually abolished.
R J Turner; M Lambrost; C Holmes; S G Katz; C S Downs; D W Collins; S P Gatt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  30     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  591-6     Citation Subset:  IM    
Department of Anaesthesia, The University of New South Wales, Prince of Wales Hospital, Sydney, NSW, Australia.
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MeSH Terms
Analysis of Variance
Anesthesia, Obstetrical / methods
Culture Techniques
Dose-Response Relationship, Drug
Methyl Ethers / pharmacology*
Muscle Contraction / drug effects*,  physiology
Muscle Relaxation / drug effects*,  physiology
Myometrium / drug effects*,  physiology
Reference Values
Sensitivity and Specificity
Reg. No./Substance:
0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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