Document Detail

The effects of serum from patients with acute liver failure on the growth and metabolism of Hep G2 cells.
MedLine Citation:
PMID:  9876094     Owner:  NLM     Status:  MEDLINE    
In many bioartificial liver systems currently being designed and evaluated for use in fulminant hepatic failure, direct contact is required between the patient's blood and the liver cells in the device. The efficacy of such devices will be influenced by the interaction of fulminant hepatic failure (FHF) patient serum with the cells. We have found that FHF serum inhibits the growth rate and the synthesis of DNA, RNA, and protein; disturbs glutathione homeostasis; and induces morphological changes in cultured human Hep G2 cells. These interactions should influence the design of bioartificial liver devices based on proliferating cell lines and indicate the requirement to pretreat FHF patient plasma to reduce the toxin load.
Q Shi; J D Gaylor; R Cousins; J Plevris; P C Hayes; M H Grant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  22     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-12     Completed Date:  1999-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1023-30     Citation Subset:  IM    
Bioengineering Unit, University of Strathclyde, Wolfson Centre, Rottenrow, Glasgow, United Kingdom.
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MeSH Terms
Blood Physiological Phenomena*
Cell Division
DNA / biosynthesis
Glutathione Transferase / metabolism
Liver / metabolism*,  pathology*
Liver Failure, Acute / blood*
Liver Neoplasms
Liver, Artificial
Protein Biosynthesis
RNA / biosynthesis
Tumor Cells, Cultured
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA; EC Transferase

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