Document Detail


The effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography.
MedLine Citation:
PMID:  10460568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amide local anaesthetics impair coagulation by inhibition of platelet function and enhanced fibrinolysis. The potential therefore exists that the presence of amide local anaesthetics in the epidural space could contribute to the therapeutic failure of an epidural autologous blood patch. Ropivacaine is an aminoamide local anaesthetic increasingly used for epidural analgesia and anaesthesia, particularly in obstetric practice. This study was undertaken to investigate whether concentrations of ropivacaine in blood, which could occur clinically in the epidural space, alter coagulation or fibrinolysis. Thromboelastography was used to assess clotting and fibrinolysis of blood to which ropivacaine had been added. Although modest alterations in maximum amplitude, coagulation time and alpha angle were observed, the effect of ropivacaine on clotting and fibrinolysis was not clinically significant. We conclude that it is unlikely that the presence of ropivacaine in the epidural space would reduce the efficacy of an early or prophylactic epidural blood patch.
Authors:
J M Porter; J McGinley; B O'Hare; G D Shorten
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  54     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-28     Completed Date:  1999-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  902-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesia & Intensive Care Medicine, Cork University Hospital, University College Cork, Wilton, Cork, Republic of Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amides / blood,  pharmacology*
Anesthetics, Local / blood,  pharmacology*
Blood Coagulation / drug effects*
Dose-Response Relationship, Drug
Female
Fibrinolysis / drug effects*
Humans
Male
Middle Aged
Partial Thromboplastin Time
Prothrombin Time
Thrombelastography
Chemical
Reg. No./Substance:
0/Amides; 0/Anesthetics, Local; 84057-95-4/ropivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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