Document Detail

The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor.
MedLine Citation:
PMID:  20561741     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of ritodrine and magnesium sulfate on maternal-fetal blood flows.
STUDY DESIGN: A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) (n=46) or magnesium sulfate (n=39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48 h after initiating therapy.
RESULTS: UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48 h. DV PI increased in women receiving MgSO(4), whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48 h in the groups. In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48 h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48 h. DV PI increased in women receiving MgSO(4), whereas it decreased in the ritodrine and control groups.
CONCLUSIONS: MgSO(4) and ritodrine affect blood flow patterns after 48 h in some maternal-fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO(4).
N Cenk Sayin; Sezer Arda; Füsun G Varol; Necdet Süt
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-06-18
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  152     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  50-4     Citation Subset:  IM    
Copyright Information:
Crown Copyright 2010. Published by Elsevier Ireland Ltd. All rights reserved.
Trakya University, Faculty of Medicine, Department of Obstetrics & Gynecology, Edirne, Turkey.
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MeSH Terms
Blood Flow Velocity / drug effects
Fetus / blood supply*,  drug effects*
Magnesium Sulfate / administration & dosage*
Middle Cerebral Artery / drug effects,  ultrasonography
Obstetric Labor, Premature / drug therapy*
Pulsatile Flow / drug effects
Ritodrine / administration & dosage*
Tocolytic Agents / administration & dosage*
Ultrasonography, Doppler
Ultrasonography, Prenatal / drug effects
Umbilical Arteries / drug effects,  ultrasonography
Umbilical Veins / drug effects,  ultrasonography
Uterine Artery / drug effects,  ultrasonography
Verapamil / administration & dosage
Young Adult
Reg. No./Substance:
0/Tocolytic Agents; 26652-09-5/Ritodrine; 52-53-9/Verapamil; 7487-88-9/Magnesium Sulfate

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