| The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor. | |
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MedLine Citation:
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PMID: 20561741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effects of ritodrine and magnesium sulfate on maternal-fetal blood flows. STUDY DESIGN: A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) (n=46) or magnesium sulfate (n=39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48 h after initiating therapy. RESULTS: UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48 h. DV PI increased in women receiving MgSO(4), whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48 h in the groups. In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48 h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48 h. DV PI increased in women receiving MgSO(4), whereas it decreased in the ritodrine and control groups. CONCLUSIONS: MgSO(4) and ritodrine affect blood flow patterns after 48 h in some maternal-fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO(4). |
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Authors:
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N Cenk Sayin; Sezer Arda; Füsun G Varol; Necdet Süt |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-06-18 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 152 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 50-4 Citation Subset: IM |
Copyright Information:
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Crown Copyright 2010. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Trakya University, Faculty of Medicine, Department of Obstetrics & Gynecology, Edirne, Turkey. ncsayin@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / drug effects Female Fetus / blood supply*, drug effects* Humans Magnesium Sulfate / administration & dosage* Middle Cerebral Artery / drug effects, ultrasonography Obstetric Labor, Premature / drug therapy* Pregnancy Pulsatile Flow / drug effects Ritodrine / administration & dosage* Tocolytic Agents / administration & dosage* Ultrasonography, Doppler Ultrasonography, Prenatal / drug effects Umbilical Arteries / drug effects, ultrasonography Umbilical Veins / drug effects, ultrasonography Uterine Artery / drug effects, ultrasonography Verapamil / administration & dosage Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Tocolytic Agents; 26652-09-5/Ritodrine; 52-53-9/Verapamil; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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