| The effects of reversible inactivation of the subthalamo-pallidal pathway on the behaviour of naive and hemiparkinsonian monkeys. | |
| | |
MedLine Citation:
|
PMID: 18638958 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
This study was designed to further investigate the role of the subthalamic nucleus (STN) and globus pallidus internus (GPi) in the pathophysiology of Parkinson's disease. The prevailing theory about the pathophysiology of Parkinson's disease (PD) predicts that there is overactivity of the subthalamo-pallidal pathway. In order to inactivate that pathway, naive and hemiparkinsonian monkeys were locally administered either muscimol (to reversibly inactivate the contralateral STN) or kynurenic acid (to reduce glutamatergic activity in the contralateral GPi). Three naive and 2 hemiparkinsonian monkeys were studied. Intra-carotid MPTP was administered to produce 2 hemiparkinsonian monkeys. Injection sites of muscimol and kynurenic acid in the brain were confirmed electrophysiologically and histologically. Injections of muscimol into the STN in naive and hemiparkinsonian monkeys caused reversible contralateral dystonia, but did not alleviate Parkinsonism. Only one kynurenic acid injection into GPi partially alleviated Parkinsonism. On the basis of the results in this study, aspects of the currently accepted hypothesis of the pathophysiology of PD cannot be confirmed. However, this study reports that the STN has an important role in the production of dystonia. This experimental model of dystonia will prove suitable for further study of both the mechanisms causing dystonia as well as for possible therapeutic approaches to its treatment. |
| | |
Authors:
|
E G Butler; D W Bourke; D I Finkelstein; M K Horne |
Related Documents
:
|
3359218 - Mossy fiber lesion reduces the probability that kainic acid will provoke ca3 hippocampa... 12940508 - Tryptophan metabolites and brain disorders. 10768488 - Effects of meconic and comenic acids on slow sodium channels of secondary neurons. 2207648 - Flight and immobility evoked by excitatory amino acid microinjection within distinct pa... 2023758 - Effect of blinking on tear elimination as evaluated by dacryoscintigraphy. 18054848 - Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver di... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 4 ISSN: 0967-5868 ISO Abbreviation: J Clin Neurosci Publication Date: 1997 Apr |
Date Detail:
|
Created Date: 2008-07-21 Completed Date: 2010-02-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
|
Languages: eng Pagination: 218-27 Citation Subset: - |
Affiliation:
|
Department of Anatomy, Monash University, Clayton, Australia; Neurosciences Department, Monash Medical Centre, Clayton, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ossification of the posterior longitudinal ligament of the cervical spine.
Next Document: No evidence of existence of functional 5-HT(1) receptors in isolated and perfused canine basilar art...