Document Detail

The effects of retinol on postprandial parameters in men with different FABP2 promoter haplotypes.
MedLine Citation:
PMID:  17447159     Owner:  NLM     Status:  MEDLINE    
The fatty acid binding protein 2 (FABP2) mediates the intestinal uptake of fatty acids. We and others have identified six FABP2 promoter polymorphisms which result in two haplotypes, A and B. Reporter-gene assays indicated different activity in FABP2 promoter alleles A and B and different responsiveness to PPAR ligands. IN SILICO analysis revealed different putative binding sites in FABP2 haplotypes for retinoid-dependent transcription factors. Therefore, we assumed that retinol supplementation may effect postprandial fat uptake differently in men with FABP2 promoter haplotype A and B. To test this hypothesis, we administered 5000 I.U. retinol/day for 8 weeks to 19 homozygotes for AA and 21 homozygotes for BB and assessed the alteration of postprandial triglycerides during this intervention. FABP2 genotype groups did not significantly differ in anthropometric and laboratory parameters. The alteration of postprandial triglycerides did not differ significantly between genotypes during intervention. This also held true after adjustment for BMI. Furthermore, in a subgroup which had a combination of promoter and common exon polymorphism, the alteration of the postprandial triglycerides did not differ between genotypes. In conclusion, the postprandial triglyceride metabolism of FABP2 promoter AA and BB did not respond differently to retinol administration even though IN SILICO analysis suggested this.
U Helwig; D Rubin; J Kiosz; W Bitter; S Schreiber; F Döring; U R Fölsch; J Schrezenmeir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  39     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-06-20     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Federal Research Centre for Nutrition and Food, Location Kiel, Kiel, Germany.
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MeSH Terms
Blood Glucose / metabolism
Computational Biology
DNA / genetics
Data Interpretation, Statistical
Exons / genetics
Fatty Acid-Binding Proteins / genetics*,  metabolism
Fatty Acids, Nonesterified / blood
Homeostasis / drug effects
Insulin / blood
Middle Aged
Postprandial Period / drug effects*
Promoter Regions, Genetic / genetics
Reverse Transcriptase Polymerase Chain Reaction
Triglycerides / blood
Vitamin A / blood,  pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/FABP2 protein, human; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 11061-68-0/Insulin; 11103-57-4/Vitamin A; 9007-49-2/DNA

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