Document Detail


The effects of restraint stress on voluntary ethanol consumption in rats.
MedLine Citation:
PMID:  10609966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty Wistar rats (Rattus norvegicus) were assigned to 4 groups of 15 rats each: ethanol stress (ES), ethanol no-stress (EN), isocaloric stress (IS) and isocaloric no-stress (IN). The effect of restraint stress on daily intake of ethanol and a 0.72% solution of glucose was examined in an ABA design (stress-no stress-stress). During the stress phases, 2 groups were subjected to daily 15-min restraint stress, whereas 2 groups were placed in different cages for 15 min as a control. All 4 groups were then given 6-hr access to their assigned liquid alone for 4 days followed by a choice between their assigned liquid and water on the 5th day. The ES group significantly increased their ethanol intake (g/kg) compared to the EN group on choice days but not on forced days. Percentage preference for ethanol was significantly greater and increased at a faster rate over the 75-day testing period compared with the EN group. However, total ethanol consumption (g/kg) and percentage preference did not vary as a function of phase. It is notable that the effects of restraint stress on ethanol self-administration persisted even after the stress schedule was removed.
Authors:
W J Lynch; M G Kushner; J M Rawleigh; J Fiszdon; M E Carroll
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental and clinical psychopharmacology     Volume:  7     ISSN:  1064-1297     ISO Abbreviation:  Exp Clin Psychopharmacol     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-28     Completed Date:  2000-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9419066     Medline TA:  Exp Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  318-23     Citation Subset:  IM; S    
Affiliation:
Department of Psychiatry, University of Minnesota, Minneapolis, 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / psychology*
Animals
Drinking
Glucose / pharmacology
Male
Rats
Rats, Wistar
Restraint, Physical
Stress, Psychological / psychology*
Grant Support
ID/Acronym/Agency:
F31 DA05650/DA/NIDA NIH HHS; R37 DA03240/DA/NIDA NIH HHS; T32 DA07097/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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