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The effects of repeated oral gavage on the health of male CD-1 mice.
MedLine Citation:
PMID:  22517091     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Oral gavage is a widely used method for administering substances to animals in pharmacological and toxicological studies. The authors evaluated whether oral gavage causes behavioral indicators of stress, increased mortality rate, alterations in food and water consumption and body weight or histological lesions in CD-1 mice. Gavage was carried out once per d for 5 d per week over 6 consecutive weeks. The mortality rate of mice in this study was 15%. Mice subjected to gavage did not undergo changes in food or water consumption during the study, and their mean body weights and relative organ weights were similar to those of mice in the control group. Serum cortisol levels at the time of euthanasia in mice in both groups were within the normal range. Histopathology showed acute esophagitis and pleurisy, indicative of perforation of the esophagus, in the two mice that died but no abnormalities in the other mice. The results suggest that animal stress and mortality related to oral gavage can be minimized when the procedure is carried out by an experienced technician.
Authors:
Regina Arantes-Rodrigues; Andreia Henriques; Rosário Pinto-Leite; Ana Faustino-Rocha; Jacinta Pinho-Oliveira; Catarina Teixeira-Guedes; Fernanda Seixas; Adelina Gama; Bruno Colaço; Aura Colaço; Paula A Oliveira
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lab animal     Volume:  41     ISSN:  1548-4475     ISO Abbreviation:  Lab Anim (NY)     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417737     Medline TA:  Lab Anim (NY)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Affiliation:
Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
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