| The effects of remifentanil on cerebral capacity in awake volunteers. | |
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MedLine Citation:
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PMID: 10702445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Remifentanil, a short-acting potent mu-opioid agonist proposed for intraoperative analgesia but also for postoperative pain therapy, has not been investigated with regard to the effects of the drug on cerebral capacity in awake humans. We assessed cerebral capacity noninvasively by means of phase-contrast magnetic resonance imaging measurement of systolic cerebrospinal fluid peak velocity in the aqueduct of Sylvius before and during infusion of remifentanil (0.1 microg. kg(-1). min(-1) IV) in normocapnic humans. Remifentanil had no significant effect on systolic cerebrospinal fluid peak velocity as compared with baseline (mean +/- SD): baseline, -4.3 +/- 1.3 cm/s versus remifentanil (0.1 microg. kg(-1). min(-1)): -4.7 +/- 1.0 cm/s. Small-dose remifentanil (0.1 microg. kg(-1). min(-1)) did not influence cerebral capacity in healthy, awake volunteers free of intracranial pathology. IMPLICATIONS: Knowledge about the influence of remifentanil on cerebral capacity is crucial before routine use of the drug in neuroanesthesia. Thus, we assessed the influence of remifentanil on cerebral capacity noninvasively by means of phase-contrast magnetic resonance imaging measurement of systolic cerebrospinal fluid peak velocity in the aqueduct of Sylvius in humans. |
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Authors:
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I H Lorenz; C Kolbitsch; C Hörmann; M Schocke; F Zschiegner; S Felber; A Benzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 90 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-03-16 Completed Date: 2000-03-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 609-13 Citation Subset: AIM; IM |
Affiliation:
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Departments of Anesthesia and Intensive Care Medicine and Magnetic Resonance Imaging, University of Innsbruck, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics, Opioid / pharmacology* Blood Volume / drug effects Brain / drug effects* Cerebrospinal Fluid / drug effects Cerebrovascular Circulation / drug effects Humans Intracranial Pressure / drug effects Piperidines / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Piperidines; 132875-61-7/remifentanil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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