Document Detail

The effects of reboxetine on autonomic and cognitive functions in healthy volunteers.
MedLine Citation:
PMID:  11594447     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Though reboxetine, a selective noradrenaline reuptake inhibitor, causes autonomic and cognitive adverse events there is a paucity of appropriately designed studies on the cognitive and autonomic effects of the drug in the literature. OBJECTIVE: To compare the effects of reboxetine on cognitive and autonomic functions with those of placebo in healthy humans. METHOD: A randomised, double-blind, crossover study of 12 healthy male volunteers aged 25 (21-27; median, range) years. Subjects orally received 4 mg reboxetine and placebo twice daily for periods of 14 days each with at least 14 days in between. Vasoconstrictory response of cutaneous vessels (VR) and skin conductance response (SCR) following sudden deep breath were employed as parameters for autonomic function. Quantitative EEG (qEEG) and psychometric tests served as parameters for cognitive function. RESULTS: Reboxetine decreased SCR and prolonged the dilation phase of VR (P<0.05). It did not affect cognitive functions such as flicker fusion frequency, choice reaction, memory and psychomotor coordination but increased slow beta (beta1) power density in the qEEG. Tiredness (n=12), dry mouth (n=9), delayed urination (n=3) and constipation (n=1) were noted with reboxetine. CONCLUSION: Sustained peripheral and/or central sympathetic activation accounts for the prolongation of VR. The decrease of SCR and typical side effects suggest a relevant antimuscarinic drug action. Chronic administration of reboxetine at therapeutic doses causes autonomic dysfunction and subjective sedation but does not impair cognitive and psychomotor abilities in healthy humans.
M Siepmann; M Mück-Weymann; P Joraschky; W Kirch
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychopharmacology     Volume:  157     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-11     Completed Date:  2002-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  202-7     Citation Subset:  IM    
Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany.
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MeSH Terms
Adrenergic Uptake Inhibitors / pharmacology*
Analysis of Variance
Autonomic Nervous System / drug effects*,  physiology
Cognition / drug effects*,  physiology
Cross-Over Studies
Double-Blind Method
Electroencephalography / drug effects
Galvanic Skin Response / drug effects,  physiology
Morpholines / pharmacology*
Vasoconstriction / drug effects,  physiology
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Morpholines; 98769-81-4/reboxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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