Document Detail

The effects of ranitidine and cysteamine on intestinal metaplasia induced by X-irradiation in rats.
MedLine Citation:
PMID:  3218508     Owner:  NLM     Status:  MEDLINE    
The influence of ranitidine and cysteamine on intestinal metaplasia was examined in 7-month-old male Crj: CD (SD) rats. At the age of 5 weeks, the animals were treated with 10 Gy doses of X-rays at 3-day intervals up to a total of 20 Gy in the gastric region, and 6 months after irradiation, the rats received either ranitidine (0.02% in diet) or cysteamine (0.1% in drinking water) for 2 months. The incidence and number of intestinal metaplasia with alkaline phosphatase-positive foci in rats given X-rays and cysteamine (group 4) were significantly low compared with those in rats given X-rays and ranitidine (group 3) (p less than 0.01). In both the pyloric and the fundic gland mucosae, the average numbers of type C metaplasia (intestinal crypts with Paneth cells) and total numbers of metaplastic foci in rats of group 3 were much higher than those in group 4 (P less than 0.05). The present results showed that the occurrence of intestinal metaplasia was significantly increased after administration of ranitidine and decreased by cysteamine.
H Watanabe; M Kamikawa; Y Nakagawa; T Takahashi; A Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  38     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-03-06     Completed Date:  1989-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1285-96     Citation Subset:  IM    
Department of Cancer Research, Hiroshima University, Japan.
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MeSH Terms
Cysteamine / pharmacology*
Intestines / drug effects,  pathology*,  radiation effects
Metaplasia / etiology
Ranitidine / pharmacology*
Rats, Inbred Strains
X-Rays / adverse effects
Reg. No./Substance:
60-23-1/Cysteamine; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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