Document Detail

The effects of on-pump and off-pump coronary artery bypass grafting on intraoperative graft flow in arterial and venous conduits defined by a flow/pressure ratio.
MedLine Citation:
PMID:  18329465     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Despite profound differences in the neurohumoral milieu in patients undergoing on-pump and off-pump coronary artery bypass grafting, it is uncertain how this affects graft blood flow. METHODS: We prospectively recorded intraoperative transit-time flow measurements (MediStim BF 2004; MediStim AS, Oslo, Norway) in all internal thoracic artery, radial artery, and long saphenous vein conduits in patients undergoing off-pump and on-pump bypass grafting by a single surgeon. We calculated a flow/pressure ratio as a ratio of mean graft flow to mean arterial pressure for all the conduits just before chest closure. RESULTS: Transit-time flow measurements were recorded in 266 grafts (203 off-pump; 63 on-pump) in 100 patients (80 off-pump; 20 on-pump). Overall, mean graft flow (milliliters per minute) was higher for all grafts in the on-pump group despite a significantly lower mean arterial pressure compared with the off-pump group (P < .05). Consequently the flow/pressure ratio was greater for all grafts in the on-pump group (internal thoracic artery 0.55 vs 0.35, radial artery 0.61 vs 0.36, long saphenous vein 0.77 vs 0.55). Overall mean graft flow was significantly greater in the long saphenous vein than in the internal thoracic artery (P < .001) and radial artery (P = .001), but there was no significant difference in mean graft flow in internal thoracic artery or radial artery grafts within each group. CONCLUSIONS: In comparison with the off-pump group, the overall mean graft flow and flow/pressure ratio were significantly higher and mean arterial pressure significantly lower for all grafts in the on-pump group. These findings are probably a result of vasodilatation resulting from cardiopulmonary bypass and reactive hyperemia resulting from a period of ischemia. There was no difference in the mean graft flow and flow/pressure ratio of arterial grafts, which were significantly less than for long saphenous vein grafts. In patients with unstable angina and/or hemodynamic instability, in whom rapid and maximum restoration of myocardial perfusion is a priority, potentially lower graft flow in arterial grafts and off-pump surgery should be considered.
Lognathen Balacumaraswami; Yasir Abu-Omar; Joseph Selvanayagam; David Pigott; David P Taggart
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  135     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-9     Citation Subset:  AIM; IM    
Department of Cardiothoracic Surgery, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
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MeSH Terms
Anastomosis, Surgical
Coronary Angiography
Coronary Artery Bypass / methods,  mortality
Coronary Artery Bypass, Off-Pump / methods*,  mortality
Coronary Circulation* / physiology
Coronary Disease / mortality,  radiography,  surgery*
Graft Rejection
Graft Survival
Great Britain
Heart Catheterization
Mammary Arteries / physiology,  transplantation
Middle Aged
Monitoring, Intraoperative / methods*
Multivariate Analysis
Prospective Studies
Pulsatile Flow*
Radial Artery / physiology,  transplantation
Statistics, Nonparametric
Survival Rate
Treatment Outcome
Vascular Patency / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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