Document Detail

The effects of prostaglandins E1, E2 and F2alpha on vagal bradycardia in the anaesthetized mouse.
MedLine Citation:
PMID:  1182348     Owner:  NLM     Status:  MEDLINE    
1 In anesthetized mice prostaglandins E1 and E2 reduced the bradycardia caused by electrical stimulation of the sectioned peripheral vagus nerve; prostaglandin F2alpha produced only a slight inhibition of the vagal response. 2 None of the prostaglandins studied affected acetylcholine-induced bradycardia. 3 Prostaglandins modify parasympathetic nerve activity in vivo presumably by a pre-synaptic action.
W Feniuk; B J Large
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  55     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-01-14     Completed Date:  1976-01-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-9     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / pharmacology
Electric Stimulation
Heart Rate / drug effects*
Mice, Inbred Strains
Parasympathetic Nervous System / drug effects
Physostigmine / pharmacology
Prostaglandins E / pharmacology*
Prostaglandins F / pharmacology*
Vagus Nerve / physiology
Reg. No./Substance:
0/Prostaglandins E; 0/Prostaglandins F; 51-84-3/Acetylcholine; 57-47-6/Physostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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