| The effects of prostaglandin E1 on interleukin-6, pulmonary function and postoperative recovery in oesophagectomised patients. | |
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MedLine Citation:
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PMID: 20014600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inflammatory reactions and tissue response after oesophagectomy are leading causes of postoperative morbidity and mortality. We evaluated the effects of intraoperative infusion of prostaglandin E1 (PGE1) on interleukin-6 (IL-6) levels, (A-a) DO2, pulmonary function and complications. This randomised double-blind clinical trial study was performed on patients undergoing transthoracic oesophagectomy due to cancer Thirty patients were randomly allocated to two groups: the PGE1 group (infusion of PGE1 20 ng kg(-1) min(-1)) and a placebo group (infusion of normal saline 0.9%). The infusion was started before induction of anaesthesia and continued until the end of the operation. The groups were comparable in basic characteristics and preoperative pulmonary function. Patients in the PGE1 group were discharged significantly earlier from the intensive care unit (72+/-9 vs 83+/-17 hours) and hospital (13+/-4 vs 18+/-8 days) (P=0.04 and 0.03, respectively). The (A-a) DO2 was significantly less in the PGE1 group at 12 and 24 hours after the operation (P=0.001, P=0.003, respectively). Postoperatively, IL-6 levels were significantly higher in the placebo group than in the PGE1 group. There were no differences in the forced expiratory volume in the first second or forced vital capacity. The findings indicate that infusion of PGE1 attenuates the increase in serum levels of IL-6 in patients undergoing esophagectomy and improves the (A-a) DO2. Stays in the intensive care unit and hospital were shorter in the PGE1 group. However, there were no differences in pulmonary complications. |
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Authors:
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E Farrokhnia; J Makarem; Z H Khan; M Mohagheghi; M Maghsoudlou; A Abdollahi |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 37 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: Australia |
Other Details:
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Languages: eng Pagination: 937-43 Citation Subset: IM |
Affiliation:
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The Cancer Institute, Imam Khomeini Medical Center, Tehran University, School of Medicine, Tehran, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alprostadil / pharmacology* Blood Gas Analysis Double-Blind Method Esophageal Neoplasms / surgery Esophagectomy / methods* Female Forced Expiratory Volume / drug effects Humans Intensive Care Units Interleukin-6 / blood* Intraoperative Care Length of Stay Male Middle Aged Oxygen / metabolism Postoperative Period Recovery of Function Vasodilator Agents / pharmacology* Vital Capacity / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Vasodilator Agents; 745-65-3/Alprostadil; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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