Document Detail


The effects of prostaglandin E1 on interleukin-6, pulmonary function and postoperative recovery in oesophagectomised patients.
MedLine Citation:
PMID:  20014600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inflammatory reactions and tissue response after oesophagectomy are leading causes of postoperative morbidity and mortality. We evaluated the effects of intraoperative infusion of prostaglandin E1 (PGE1) on interleukin-6 (IL-6) levels, (A-a) DO2, pulmonary function and complications. This randomised double-blind clinical trial study was performed on patients undergoing transthoracic oesophagectomy due to cancer Thirty patients were randomly allocated to two groups: the PGE1 group (infusion of PGE1 20 ng kg(-1) min(-1)) and a placebo group (infusion of normal saline 0.9%). The infusion was started before induction of anaesthesia and continued until the end of the operation. The groups were comparable in basic characteristics and preoperative pulmonary function. Patients in the PGE1 group were discharged significantly earlier from the intensive care unit (72+/-9 vs 83+/-17 hours) and hospital (13+/-4 vs 18+/-8 days) (P=0.04 and 0.03, respectively). The (A-a) DO2 was significantly less in the PGE1 group at 12 and 24 hours after the operation (P=0.001, P=0.003, respectively). Postoperatively, IL-6 levels were significantly higher in the placebo group than in the PGE1 group. There were no differences in the forced expiratory volume in the first second or forced vital capacity. The findings indicate that infusion of PGE1 attenuates the increase in serum levels of IL-6 in patients undergoing esophagectomy and improves the (A-a) DO2. Stays in the intensive care unit and hospital were shorter in the PGE1 group. However, there were no differences in pulmonary complications.
Authors:
E Farrokhnia; J Makarem; Z H Khan; M Mohagheghi; M Maghsoudlou; A Abdollahi
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  37     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  937-43     Citation Subset:  IM    
Affiliation:
The Cancer Institute, Imam Khomeini Medical Center, Tehran University, School of Medicine, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alprostadil / pharmacology*
Blood Gas Analysis
Double-Blind Method
Esophageal Neoplasms / surgery
Esophagectomy / methods*
Female
Forced Expiratory Volume / drug effects
Humans
Intensive Care Units
Interleukin-6 / blood*
Intraoperative Care
Length of Stay
Male
Middle Aged
Oxygen / metabolism
Postoperative Period
Recovery of Function
Vasodilator Agents / pharmacology*
Vital Capacity / drug effects
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Vasodilator Agents; 745-65-3/Alprostadil; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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