Document Detail

The effects of prostacyclin (PGI2) on haematological and haemodynamic parameters, and lung histology in puppies undergoing cardiopulmonary bypass surgery with profound hypothermia.
MedLine Citation:
PMID:  3883367     Owner:  NLM     Status:  MEDLINE    
Puppies 6-12 kg underwent cardiopulmonary bypass with profound hypothermia. Thirteen animals received 200 ng kg-1 min-1 of PGI2 during bypass whilst 11 control animals received equivalent volumes of glycine buffer (placebo) over a similar period. Results indicated preservation of platelets, leukocytes and fibrinogen levels, together with shortened activated partial thromboplastin times and fewer fibrinogen degradation products post-bypass in PGI2-treated animals. There was an initial fall in blood pressure and systemic vascular resistance in PGI2 treated animals, but pulmonary pressures and resistances, cardiac outputs, and heart rates showed no significant differences from controls. Higher and more satisfactory end of bypass and post-bypass blood pressure levels, together with a lesser fall-off in mean total pulmonary compliance, and shortened bypass times were achieved in treated animals. PGI2 appeared to afford some protection against lung damage as observed by histological studies. All beneficial effects appeared to be significantly greater amongst smaller animals. The results indicate possible benefits from the use of PGI2 in infant open heart surgery.
M B Starling; J M Neutze; D G Hill; M Jagusch; J F Cleland; A Johns; R L Elliott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  17     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-04-16     Completed Date:  1985-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  11-29     Citation Subset:  IM    
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MeSH Terms
Blood Platelets / drug effects
Cardiopulmonary Bypass*
Epoprostenol / pharmacology*
Fibrinogen / metabolism
Hemodynamics / drug effects*
Hypothermia, Induced*
Leukocyte Count
Leukocytes / drug effects
Lung / drug effects*,  pathology
Platelet Count
Reg. No./Substance:
35121-78-9/Epoprostenol; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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