Document Detail

The effects of prenatal exposure to low-level cadmium, lead and selenium on birth outcomes.
MedLine Citation:
PMID:  24875909     Owner:  NLM     Status:  In-Data-Review    
To evaluate the current maternal and fetal exposure to cadmium (Cd), lead (Pb) and selenium (Se), and their potential effect on newborn birth outcomes, a cross-sectional study involving an assessment of the levels of these three metals in maternal blood, urine and umbilical cord blood was conducted in 209 pregnant women living in Eastern China. The maternal blood, urine and cord blood samples were collected and measured with inductively coupled plasma mass spectrometry (ICP-MS). The maternal blood concentrations of Cd, Pb and Se (the geometric means (GMs) were 0.48, 39.50 and 143.53μgL(-1)) were significantly higher than and correlated with those in the cord blood (GM: 0.09, 31.62 and 124.61μgL(-1)). In the urine samples, the GMs for Cd, Pb and Se were 0.13, 0.48, and 4.78μgL(-1), respectively. Passive smoking was found to positively correlate with urine Cd (r=0.16) and negatively correlate with urine Se (r=-0.29). The maternal blood Se level was negatively associated with the cord Cd levels (r=-0.41). The blood Cd concentration in the mother could significantly affect the newborn birth weight (r=-0.22), but it was not correlated with birth height. We identified cord Se as a new factor which significantly correlated with birth weight. In conclusion, maternal Cd, Pb, Se exposure correlated with their umbilical cord concentration, and maternal Cd exposure might affect the newborn birth weight. Increasing the Se intake might reduce the cord blood Cd concentration and promote the fetal growth.
Hong Sun; Wen Chen; Dongyue Wang; Yinlong Jin; Xiaodong Chen; Yan Xu
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Publication Detail:
Type:  Journal Article     Date:  2014-04-06
Journal Detail:
Title:  Chemosphere     Volume:  108     ISSN:  1879-1298     ISO Abbreviation:  Chemosphere     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-05-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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