Document Detail


The effects of prenatal cocaine use on infant development.
MedLine Citation:
PMID:  18243651     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effect of prenatal cocaine use on infant physical, cognitive, and motor development, and temperamental characteristics, controlling for other factors that affect infant development. Women were, on average, 26.8 years old, had 12 years of education, and 46% were African American. During the first trimester, 18% were frequent users of cocaine (> or =1 line/day). The infants were, on average, 14.6 months old at this follow-up phase. Women who used cocaine during pregnancy rated their infants as more fussy/difficult and unadaptable than did women who did not use cocaine. Cocaine use in the second trimester was associated with significantly lower motor scores on the Bayley Scales of Infant Development (BSID) [N. Bayley, Manual for the Bayley Scales of Infant Development, Psychological Corporation, New York, 1969.]. There was no effect of prenatal cocaine use on BSID mental performance or on growth. These findings are consistent with other reports in the literature and with the hypothesis that prenatal cocaine exposure affects development through changes in neurotransmitter systems.
Authors:
Gale A Richardson; Lidush Goldschmidt; Jennifer Willford
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-12-28
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  30     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-05-28     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-106     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Child Development / drug effects*
Cocaine / toxicity*
Cocaine-Related Disorders / psychology
Cognition / physiology
Data Interpretation, Statistical
Female
Growth / drug effects
Humans
Infant
Infant Behavior / drug effects
Infant, Newborn
Longitudinal Studies
Movement / physiology
Neuropsychological Tests
Pregnancy
Prenatal Exposure Delayed Effects / psychology*
Prospective Studies
Regression Analysis
Substance-Related Disorders / psychology
Temperament / physiology
Grant Support
ID/Acronym/Agency:
DA 05460/DA/NIDA NIH HHS; R01 DA008916/DA/NIDA NIH HHS; R29 DA005460/DA/NIDA NIH HHS; R29 DA005460-05/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
I5Y540LHVR/Cocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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