Document Detail


The effects of prenatal alcohol exposure on odor associative learning in rats.
MedLine Citation:
PMID:  3226376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol was administered to pregnant females via a liquid diet that contained either 35% ethanol-derived calories (35% EDC) or 0% EDC on gestation days 6-20. An ad lib lab chow group (LC) was also included. In Experiment 1, odor-aversion learning was examined in 10-day-old offspring. While both the 0% EDC and LC groups displayed odor aversions, the 35% EDC offspring did not. In Experiment 2, learning was assessed in an appetitive paradigm in three-day-old offspring. Once again, the 35% EDC offspring showed no evidence of learning. Experiment 3 examined odor-aversion learning in adults. Both alcohol-exposed offspring and controls learned the odor association equally well. These findings suggest that odor associative learning is a sensitive indicator for alcohol-related learning deficits in rat pups although these deficits may dissipate as the offspring matures. Since odor associations play a critical role in neonatal behaviors, these deficits may help explain other behavioral anomalies noted following prenatal alcohol exposure.
Authors:
S Barron; W A Gagnon; S N Mattson; L E Kotch; L S Meyer; E P Riley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  10     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
Affiliation:
Psychology Department State University of New York, Albany 12222.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Avoidance Learning / drug effects*,  physiology
Central Nervous System / drug effects*
Conditioning, Classical
Ethanol / toxicity*
Female
Male
Odors
Olfactory Pathways / drug effects*,  physiology
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Grant Support
ID/Acronym/Agency:
AA00077/AA/NIAAA NIH HHS; AA03249/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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