Document Detail


The effects of prenatal administration of azo dyes on testicular development in the mouse: a structure activity profile of dyes derived from benzidine, dimethylbenzidine, or dimethoxybenzidine.
MedLine Citation:
PMID:  8449389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In mice and rats, prenatal exposure to the dye Congo red permanently reduces the number of germ cells in male and female offspring. In the current investigation, nine other dyes structurally related to Congo red were examined for developmental testicular toxicity. In this study, the structural component of the dyes responsible for the prenatal induction of germ cell aplasia was identified. We found that only benzidine-based dyes altered testicular development and caused hypospermatogenesis in mice during adulthood. Dimethyl- and dimethoxybenzidine-based dyes were without effect. Pregnant mice were dosed orally on Days 8-12 of gestation with a benzidine-, dimethylbenzidine-, or a dimethoxybenzidine-based dye and the testes of 45- to 50-day-old male offspring were examined. The testes of postpubertal male offspring exposed to the benzidine-based dyes, Congo red, diamine blue, and Chlorazol Black E, were small and contained some tubules completely devoid of germ cells, but the dimethylbenzidine-based dyes, trypan blue, Evans blue, and benzopurpurin 4B, and the dimethoxybenzidine-based dye, Chicago sky blue, did not alter testicular development in this manner. Azoic diazo component 48, a dimethoxybenzidine congener, and two other diazo dyes, naphthol blue black and Sudan III, were also without effect on the germ cells. Experiments with Chlorazol Black E (CBE) indicate that the period of susceptibility in the male fetus is limited to the period of primordial germ cell migration and division. When CBE was administered on Days 8-10 of gestation it reduced testis weight after puberty by 30%, while treatment after Day 13 did not affect testicular function.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
L E Gray; J S Ostby
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fundamental and applied toxicology : official journal of the Society of Toxicology     Volume:  20     ISSN:  0272-0590     ISO Abbreviation:  Fundam Appl Toxicol     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-15     Completed Date:  1993-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200838     Medline TA:  Fundam Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Affiliation:
Developmental Reproductive Biology Section, RTB, DTD, USEPA, Research Triangle Park, North Carolina 27711.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology
Aging / physiology
Animals
Azo Compounds / toxicity*
Benzidines / toxicity*
Body Weight / drug effects
Coloring Agents / toxicity*
Dianisidine / toxicity*
Epididymis / drug effects
Female
Male
Mice
Organ Size / drug effects
Pregnancy
Prenatal Exposure Delayed Effects*
Spermatogenesis / drug effects
Structure-Activity Relationship
Testis / anatomy & histology,  drug effects*,  growth & development
Chemical
Reg. No./Substance:
0/Azo Compounds; 0/Benzidines; 0/Coloring Agents; 119-90-4/Dianisidine; 119-93-7/2-tolidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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