Document Detail

The effects of pregnancy and parturition on the substance P content of the rat uterus: uterine growth is accompanied by hypertrophy of its afferent innervation.
MedLine Citation:
PMID:  7576603     Owner:  NLM     Status:  MEDLINE    
The afferent innervation of the uterus might be expected to grow during pregnancy as the size of the uterus increases. Substance P-like immunoreactivity (SPLI) has been measured as a means of monitoring the changes in the afferent innervation of the urogenital tract of rats during pregnancy and following parturition. The great growth of uterine tissue during pregnancy causes an overall decrease in SPLI concentrations during pregnancy, but it has been found that the amount of SPLI present per uterine horn increases nearly 3-fold by the end of pregnancy. This increase is greater in uterine horns that contain more fetuses, suggesting that the SPLI innervation expands to a greater extent in uterine horns that undergo greater degrees of hypertrophy. There is a significant correlation between SPLI content and the number or total weight of fetuses throughout the latter two-thirds of pregnancy. There is a fall in SPLI content of uterine horns following parturition, but not to a statistically significant degree, and this may be related to the release of the peptide during parturition.
S Amira; J F Morrison; K M Rayfield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental physiology     Volume:  80     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  645-50     Citation Subset:  IM    
Department of Physiology, University of Leeds, UK.
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MeSH Terms
Afferent Pathways / growth & development
Body Weight
Fetus / anatomy & histology
Labor, Obstetric*
Litter Size
Osmolar Concentration
Pregnancy, Animal / physiology*
Rats, Wistar
Substance P / metabolism*
Tissue Distribution
Uterus / growth & development,  innervation,  metabolism*
Grant Support
//Wellcome Trust
Reg. No./Substance:
33507-63-0/Substance P

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