| The effects of pregnancy on the exacerbation and development of maternal allergic respiratory disease. | |
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MedLine Citation:
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PMID: 19845451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The T-helper 2 (T(H)2) bias associated with pregnancy may predispose the pregnant mother to the development or exacerbation of allergic disease. To determine the effects of pregnancy on pre-existing maternal sensitization, we sensitized BALB/c mice before breeding by two intratracheal aspiration (IA) exposures to the fungal allergen, Metarhizium anisopliae crude antigen (MACA). Some mice also received three IA exposures to MACA on gestational days 11, 15, and 19. After weaning, all mice were challenged IA with MACA before killing. To determine the effects of pregnancy on susceptibility to future sensitization, na??ve parous and nulliparous BALB/c mice were sensitized by three IA exposures to MACA or to Hank's buffered salt solution vehicle control. Pregnancy did not have a significant effect on individual inflammatory parameters (airway responsiveness to methacholine, total serum and bronchoalveolar lavage fluid (BALF) IgE, BALF total protein, lactate dehydrogenase activity, and total and differential cell counts) following allergen challenge in sensitized mice, regardless of post-breeding allergen exposure. In conclusion there was a weak inhibition of the overall response in mice exposed to allergen during pregnancy compared to identically treated nulliparous mice. In contrast, parous mice that did not encounter allergen post-breeding tended to have exacerbated responses. Parity had no significant impact on future susceptibility to sensitization. |
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Authors:
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Cherie M Pucheu-Haston; Lisa B Copeland; Najwa Haykal-Coates; Marsha D W Ward |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of immunotoxicology Volume: 6 ISSN: 1547-6901 ISO Abbreviation: J Immunotoxicol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101201960 Medline TA: J Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 276-84 Citation Subset: IM |
Affiliation:
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Curriculum in Toxicology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27711, USA. Pucheu-Haston.Cherie@epa.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Airway Resistance / drug effects, physiology Allergens / administration & dosage, immunology* Animals Antigens, Fungal / administration & dosage, immunology* Bronchial Hyperreactivity / immunology*, pathology, physiopathology Female Male Maternal Exposure Mice Mice, Inbred BALB C Mitosporic Fungi / immunology* Pregnancy Pregnancy Complications / immunology* Spores, Fungal / immunology |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antigens, Fungal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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