Document Detail

The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid-sparing effect in patients undergoing off-pump coronary artery bypass grafting.
MedLine Citation:
PMID:  22234017     Owner:  NLM     Status:  MEDLINE    
The clinical study was designed to evaluate and compare single preoperative dose of pregabalin to a placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side-effects. It was a randomized, double-blind, placebo-controlled, parallel assignment, efficacy study. The study was done at a tertiary university hospital. This study was a comparison between two groups of 30 adult patients scheduled for elective off pump coronary artery bypass surgery. In the control group, the patients were given placebo capsules, and in the pregabalin group, the patients were given pregabalin 150 mg capsule orally 1 h before surgery. The patients were compared for hemodynamic changes before the start of the surgery, after induction, 1, 3, and 5 min after intubation. Additionally, fentanyl requirement during surgery and the first postoperative day was also compared. The present study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery attenuated the pressor response to tracheal intubation in adults, but the drug did not show any effect on perioperative opioid consumption and was devoid of side-effects in the given dose.
Ayya Syama Sundar; Rajeshkumar Kodali; Sajith Sulaiman; Harish Ravullapalli; Ranjith Karthekeyan; Mahesh Vakamudi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of cardiac anaesthesia     Volume:  15     ISSN:  0974-5181     ISO Abbreviation:  Ann Card Anaesth     Publication Date:    2012 Jan-Mar
Date Detail:
Created Date:  2012-01-11     Completed Date:  2012-05-11     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  9815987     Medline TA:  Ann Card Anaesth     Country:  India    
Other Details:
Languages:  eng     Pagination:  18-25     Citation Subset:  IM    
Department of Cardiac Anaesthesiology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India.
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MeSH Terms
Analgesics, Opioid / therapeutic use*
Coronary Artery Bypass, Off-Pump*
Double-Blind Method
Fentanyl / therapeutic use
Hemodynamics / drug effects
Intubation, Intratracheal*
Middle Aged
Stress, Psychological / prevention & control*
gamma-Aminobutyric Acid / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Analgesics, Opioid; 437-38-7/Fentanyl; 55JG375S6M/pregabalin; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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