Document Detail

The effects of pre- and post-pregnancy inflammatory bowel disease diagnosis on birth outcomes.
MedLine Citation:
PMID:  21138456     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inflammatory bowel diseases are frequent in women at their optimum age for reproduction. Possible effects on pregnancy are therefore of interest.
AIM: To assess pregnancy outcomes in 212 women: 135 of whom were diagnosed with inflammatory bowel disease before pregnancy and 77 after pregnancy.
METHODS: A clinical birth database was examined retrospectively. Odds ratios (ORs) for the main outcomes were calculated with 95% confidence intervals; these were adjusted for confounding factors.
RESULTS: Overall, pregnancy outcomes were good. No increased risk of preterm births or need for neonatal intensive care was observed. However, women with inflammatory bowel disease had more growth-retarded newborns, at an adjusted OR of 2.08 (1.26-3.44) and the mode of delivery was more frequently Caesarean section, with an OR of 2.75 (1.82-4.16). In the women who were diagnosed with inflammatory bowel disease after the pregnancy, we found no difference in the obstetric outcome as compared with the general obstetric population.
CONCLUSIONS: Most women with inflammatory bowel disease have a normal pregnancy outcome and, overall, inflammatory bowel disease during pregnancy poses low-to-moderate risks, the main concern being increased risk of impaired foetal growth. Normal maternal weight gain during pregnancy, possibly indicating a more stable disease, appeared to protect against adverse outcomes.
K Raatikainen; J Mustonen; M O Pajala; M Heikkinen; S Heinonen
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Publication Detail:
Type:  Journal Article     Date:  2010-12-08
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  33     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-06-03     Revised Date:  2011-06-17    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.
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MeSH Terms
Age Factors
Cesarean Section
Infant, Low Birth Weight
Infant, Newborn
Inflammatory Bowel Diseases / diagnosis*
Maternal Age
Odds Ratio
Pregnancy Complications / diagnosis*
Pregnancy Outcome*
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Young Adult
Comment In:
Aliment Pharmacol Ther. 2011 Jun;33(11):1253-4   [PMID:  21535053 ]

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