| The effects of pre- and post-pregnancy inflammatory bowel disease diagnosis on birth outcomes. | |
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MedLine Citation:
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PMID: 21138456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inflammatory bowel diseases are frequent in women at their optimum age for reproduction. Possible effects on pregnancy are therefore of interest. AIM: To assess pregnancy outcomes in 212 women: 135 of whom were diagnosed with inflammatory bowel disease before pregnancy and 77 after pregnancy. METHODS: A clinical birth database was examined retrospectively. Odds ratios (ORs) for the main outcomes were calculated with 95% confidence intervals; these were adjusted for confounding factors. RESULTS: Overall, pregnancy outcomes were good. No increased risk of preterm births or need for neonatal intensive care was observed. However, women with inflammatory bowel disease had more growth-retarded newborns, at an adjusted OR of 2.08 (1.26-3.44) and the mode of delivery was more frequently Caesarean section, with an OR of 2.75 (1.82-4.16). In the women who were diagnosed with inflammatory bowel disease after the pregnancy, we found no difference in the obstetric outcome as compared with the general obstetric population. CONCLUSIONS: Most women with inflammatory bowel disease have a normal pregnancy outcome and, overall, inflammatory bowel disease during pregnancy poses low-to-moderate risks, the main concern being increased risk of impaired foetal growth. Normal maternal weight gain during pregnancy, possibly indicating a more stable disease, appeared to protect against adverse outcomes. |
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Authors:
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K Raatikainen; J Mustonen; M O Pajala; M Heikkinen; S Heinonen |
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Publication Detail:
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Type: Journal Article Date: 2010-12-08 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 33 ISSN: 1365-2036 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-06-03 Revised Date: 2011-06-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 333-9 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland. kaisa.e.raatikainen@kuh.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Cesarean Section Female Humans Infant, Low Birth Weight Infant, Newborn Inflammatory Bowel Diseases / diagnosis* Maternal Age Odds Ratio Pregnancy Pregnancy Complications / diagnosis* Pregnancy Outcome* Retrospective Studies Risk Assessment Risk Factors Time Factors Young Adult |
| Comments/Corrections | |
Comment In:
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Aliment Pharmacol Ther. 2011 Jun;33(11):1253-4
[PMID:
21535053
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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