Document Detail

The effects of postural change and exercise on renal haemodynamics in familial dysautonomia.
MedLine Citation:
PMID:  8400819     Owner:  NLM     Status:  MEDLINE    
Cardiovascular instability is a prominent manifestation of familial dysautonomia [FD] while renal insufficiency occurs in a large number of adult FD patients. To determine if there was a causative relationship, renal artery blood flow velocity using Doppler technology, was recorded and the ratio of the peak systolic velocity (point A) to the end diastolic velocity (point B) was calculated. The A/B ratio was assessed in response to change of position and exercise, and was correlated with renal function, heart rate and systemic blood pressure. Studies were performed in 54 FD patients with a mean age of 24 years +/- 9.8 years, and 20 controls, with a mean age of 24.7 +/- 7.6 years. In the supine position, the mean A/B ratios were not significantly different, but FD subjects had a significantly higher mean blood pressure and heart rate than controls. When erect and post exercise, the mean A/B ratios in FD subjects were significantly higher than controls, p = 0.0004 and p = 0.0001, respectively. In contrast to controls, when FD subjects were standing erect and post exercise, mean blood pressure decreased significantly without a significant change in heart rate. When FD subjects were divided into two groups based on their creatinine clearance value, the group with the lower creatinine clearances had a significantly greater fall in diastolic pressure when they moved from the supine to the erect position. Our results indicate that noninvasive Doppler techniques are helpful in detecting changes in renal blood flow in subjects with familial dysautonomia.(ABSTRACT TRUNCATED AT 250 WORDS)
F B Axelrod; J S Glickstein; J Weider; M C Gluck; D Friedman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  3     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Department of Paediatrics, New York University Medical Center, NY.
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MeSH Terms
Blood Pressure / physiology
Dysautonomia, Familial / physiopathology*,  ultrasonography
Exercise / physiology*
Follow-Up Studies
Glomerular Filtration Rate
Heart Rate / physiology
Hemodynamics / physiology
Middle Aged
Posture / physiology*
Renal Circulation / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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