| The effects of post-heparin plasma lipases on anti-Xa clotting activity. | |
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MedLine Citation:
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PMID: 3992526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of hepatic triglyceride lipase (HTGL) and lipoprotein lipase (LPL) on the anti-Xa clotting activity of plasma were studied. LPL had no effect, but HTGL enhanced anti-Xa activity. This enhancement was shown to be due to a time-dependent action of HTGL on lipoproteins. These results could explain the increases in anti-Xa clotting activity previously observed after injection of heparin analogues, SSHA and SP54, which are potent releasers of lipase enzymes. |
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Authors:
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S P Williams; T W Barrowcliffe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis research Volume: 37 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1985 Feb |
Date Detail:
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Created Date: 1985-06-10 Completed Date: 1985-06-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 371-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation / drug effects Factor X / antagonists & inhibitors* Factor Xa Heparin / diagnostic use* Humans Kinetics Lipase / blood, pharmacology* Lipoprotein Lipase / blood, pharmacology* Liver / enzymology Male Rats |
| Chemical | |
Reg. No./Substance:
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9001-29-0/Factor X; 9005-49-6/Heparin; EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase; EC 3.4.21.6/Factor Xa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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