| The effects of physical exercise on the cigarette smoke-induced pulmonary oxidative response. | |
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MedLine Citation:
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PMID: 19683592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies have shown that the oxidative power of cigarettes is related to the pathogenesis of several pulmonary diseases and that regular physical exercise contributes significantly to reducing the deleterious effects of cigarettes. The objective of the present study was to investigate the therapeutic effects of physical exercise on histological and oxidative stress markers in animals exposed to cigarette smoke. Thirty-six male, eight-week-old C57BL-6 mice were divided into four groups (n = 9 for each group): control, exercise, cigarette smoke, and cigarette smoke plus exercise. The cigarette smoke (CS) groups were exposed to cigarette smoke 3 times/day (4 cigarettes/session) for 60 consecutive days. The exercise groups were submitted to swimming physical training 5 days/week for eight weeks. Forty-eight hours after the last exercise and cigarette exposure, the animals were sacrificed using cervical traction. The right lung was removed, processed, and stored for future analysis. In addition to the analysis of collagen content (hydroxyproline), oxidant production (anion superoxide), antioxidant enzyme activity (SOD and CAT), and lipid and protein oxidative damage (TBARS and Carbonylation), histological and morphological studies were performed. The results revealed that the animals exposed to cigarette smoke showed enlargement and destruction of the alveolar septum and increases in the numbers of macrophages and neutrophils, as well as in the amount of collagen. Our results also showed a decrease in the volume density of elastic fibers and an increase in the volume density of airspaces. However, physical exercise partially improved these markers. Additionally, physical exercise decreased oxidant production and increased the activity of the enzymatic antioxidant defense system, but did not reverse lipid and protein oxidative damage induced by cigarette smoke. These results suggest that physical training partially improves histological and oxidative stress parameters in the lungs of animals chronically exposed to cigarette smoke and that other therapies can contribute to potentiate these effects. |
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Authors:
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Bruno T Menegali; Renata T Nesi; Priscila S Souza; Luciano A Silva; Paulo C L Silveira; Samuel S Valen??a; Ricardo A Pinho |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-14 |
Journal Detail:
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Title: Pulmonary pharmacology & therapeutics Volume: 22 ISSN: 1522-9629 ISO Abbreviation: Pulm Pharmacol Ther Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9715279 Medline TA: Pulm Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 567-73 Citation Subset: IM |
Affiliation:
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Exercise Biochemistry and Physiology Laboratory, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, Santa Catarina, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catalase / metabolism Hydroxyproline / metabolism Lactic Acid / blood Lipid Peroxidation / drug effects Lung / physiology* Macrophages / drug effects Male Mice Mice, Inbred C57BL Neutrophils / drug effects Oxidation-Reduction Oxidative Stress / physiology* Physical Conditioning, Animal / physiology* Protein Carbonylation / drug effects Smoking / pathology* Superoxide Dismutase / metabolism Superoxides / metabolism |
| Chemical | |
Reg. No./Substance:
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11062-77-4/Superoxides; 50-21-5/Lactic Acid; 51-35-4/Hydroxyproline; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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