Document Detail


The effects of physical exercise on the cigarette smoke-induced pulmonary oxidative response.
MedLine Citation:
PMID:  19683592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies have shown that the oxidative power of cigarettes is related to the pathogenesis of several pulmonary diseases and that regular physical exercise contributes significantly to reducing the deleterious effects of cigarettes. The objective of the present study was to investigate the therapeutic effects of physical exercise on histological and oxidative stress markers in animals exposed to cigarette smoke. Thirty-six male, eight-week-old C57BL-6 mice were divided into four groups (n = 9 for each group): control, exercise, cigarette smoke, and cigarette smoke plus exercise. The cigarette smoke (CS) groups were exposed to cigarette smoke 3 times/day (4 cigarettes/session) for 60 consecutive days. The exercise groups were submitted to swimming physical training 5 days/week for eight weeks. Forty-eight hours after the last exercise and cigarette exposure, the animals were sacrificed using cervical traction. The right lung was removed, processed, and stored for future analysis. In addition to the analysis of collagen content (hydroxyproline), oxidant production (anion superoxide), antioxidant enzyme activity (SOD and CAT), and lipid and protein oxidative damage (TBARS and Carbonylation), histological and morphological studies were performed. The results revealed that the animals exposed to cigarette smoke showed enlargement and destruction of the alveolar septum and increases in the numbers of macrophages and neutrophils, as well as in the amount of collagen. Our results also showed a decrease in the volume density of elastic fibers and an increase in the volume density of airspaces. However, physical exercise partially improved these markers. Additionally, physical exercise decreased oxidant production and increased the activity of the enzymatic antioxidant defense system, but did not reverse lipid and protein oxidative damage induced by cigarette smoke. These results suggest that physical training partially improves histological and oxidative stress parameters in the lungs of animals chronically exposed to cigarette smoke and that other therapies can contribute to potentiate these effects.
Authors:
Bruno T Menegali; Renata T Nesi; Priscila S Souza; Luciano A Silva; Paulo C L Silveira; Samuel S Valen??a; Ricardo A Pinho
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-14
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  22     ISSN:  1522-9629     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  567-73     Citation Subset:  IM    
Affiliation:
Exercise Biochemistry and Physiology Laboratory, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, Santa Catarina, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Catalase / metabolism
Hydroxyproline / metabolism
Lactic Acid / blood
Lipid Peroxidation / drug effects
Lung / physiology*
Macrophages / drug effects
Male
Mice
Mice, Inbred C57BL
Neutrophils / drug effects
Oxidation-Reduction
Oxidative Stress / physiology*
Physical Conditioning, Animal / physiology*
Protein Carbonylation / drug effects
Smoking / pathology*
Superoxide Dismutase / metabolism
Superoxides / metabolism
Chemical
Reg. No./Substance:
11062-77-4/Superoxides; 50-21-5/Lactic Acid; 51-35-4/Hydroxyproline; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

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