| The effects of phenytoin on rat development: an animal model system for fetal hydantoin syndrome. | |
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MedLine Citation:
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PMID: 7199765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An animal model system has been established which reproduces some of the features of the Fetal Hydantoin Syndrome. This pattern of altered growth and development includes growth retardation, craniofacial anomalies, distal phalangeal hypoplasia, and mental deficiency. Rats exposed in utero to phenytoin on gestational days 9, 11, and 13 exhibited fetal onset growth retardation, abnormalities of the craniofacial region and axial skeleton. In addition, the exposed offspring had significantly lower fetal weights, a shortened snout and a high-arched, irregular palate, and significant delays in skeletal maturation. These abnormalities resemble those reported for the Fetal Hydantoin Syndrome and provide a means to study the effect of phenytoin on the morphological and biochemical development of the fetus. |
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Authors:
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C A Lorente; M S Tassinari; D A Keith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Teratology Volume: 24 ISSN: 0040-3709 ISO Abbreviation: Teratology Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1982-05-12 Completed Date: 1982-05-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0153257 Medline TA: Teratology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 169-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Animals Disease Models, Animal* Female Growth Disorders / chemically induced Humans Limb Deformities, Congenital Mental Retardation / chemically induced Phenytoin / adverse effects* Pregnancy Rats Rodent Diseases / chemically induced* |
| Grant Support | |
ID/Acronym/Agency:
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DE 7008/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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