Document Detail


The effects of phenytoin on rat development: an animal model system for fetal hydantoin syndrome.
MedLine Citation:
PMID:  7199765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An animal model system has been established which reproduces some of the features of the Fetal Hydantoin Syndrome. This pattern of altered growth and development includes growth retardation, craniofacial anomalies, distal phalangeal hypoplasia, and mental deficiency. Rats exposed in utero to phenytoin on gestational days 9, 11, and 13 exhibited fetal onset growth retardation, abnormalities of the craniofacial region and axial skeleton. In addition, the exposed offspring had significantly lower fetal weights, a shortened snout and a high-arched, irregular palate, and significant delays in skeletal maturation. These abnormalities resemble those reported for the Fetal Hydantoin Syndrome and provide a means to study the effect of phenytoin on the morphological and biochemical development of the fetus.
Authors:
C A Lorente; M S Tassinari; D A Keith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Teratology     Volume:  24     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced*
Animals
Disease Models, Animal*
Female
Growth Disorders / chemically induced
Humans
Limb Deformities, Congenital
Mental Retardation / chemically induced
Phenytoin / adverse effects*
Pregnancy
Rats
Rodent Diseases / chemically induced*
Grant Support
ID/Acronym/Agency:
DE 7008/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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