Document Detail

The effects of perfluoro-octanoic acid on hepatic peroxisome proliferation and related parameters show no sex-related differences in mice.
MedLine Citation:
PMID:  1497616     Owner:  NLM     Status:  MEDLINE    
Male and female C57Bl/6 mice were administered perfluor-octanoic acid PFOA; 0.02-0.05% w/w; 5-10 days) in their diet. This treatment resulted in a several-fold induction of hepatic peroxisomal fatty acid beta-oxidation (monitored as increases in cyanide-insensitive palmitoyl-CoA oxidation, lauroyl-CoA oxidase and catalase activity) in all animals. The protein content of the hepatic mitochondrial fraction was also increased in all mice exposed to PFOA. Furthermore, studies on xenobiotic-metabolizing enzymes revealed no sex-related difference in the response to PFOA. All mice demonstrated a dramatic increase in omega-hydroxylation of lauric acid. Cytosolic epoxide hydrolase, glutathione transferase and DT-diaphorase activities were increased about 2-5-fold. These results with mice differ dramatically from previous studies and our own experiments here with Wistar rats, in which exposure to PFOA causes hepatic peroxisome proliferation in male animals, whereas females are unaffected.
A K Sohlenius; K Andersson; J W DePierre
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  285 ( Pt 3)     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-10     Completed Date:  1992-09-10     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  779-83     Citation Subset:  IM    
Department of Biochemistry, Wallenberg Laboratory, Stockholm University, Sweden.
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MeSH Terms
Catalase / metabolism
Cytosol / drug effects,  metabolism
Fluorocarbons / pharmacology*
Lauric Acids / metabolism
Liver / drug effects*,  metabolism,  ultrastructure
Mice, Inbred C57BL
Microbodies / drug effects*,  metabolism,  ultrastructure
Microsomes, Liver / drug effects,  metabolism
Mitochondria, Liver / drug effects,  metabolism
Octanoic Acids / pharmacology*
Palmitoyl Coenzyme A / metabolism
Proteins / metabolism
Rats, Inbred Strains
Sex Characteristics*
Reg. No./Substance:
0/Fluorocarbons; 0/Lauric Acids; 0/Octanoic Acids; 0/Proteins; 143-07-7/lauric acid; 1763-10-6/Palmitoyl Coenzyme A; 335-67-1/perfluorooctanoic acid; EC

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