Document Detail

The effects of partial and total amniotic fluid exclusion on excisional fetal rabbit wounds.
MedLine Citation:
PMID:  1952737     Owner:  NLM     Status:  MEDLINE    
Previous studies have consistently demonstrated that fetal rabbit excisional wounds exposed to amniotic fluid do not heal in utero. This study examines fetal wounds covered to exclude amniotic fluid. Full-thickness excisional wounds were created on fetal rabbits on day 25 of gestation. The following three treatment groups were examined: uncovered (n = 19 live); covered, a silicone cover was sutured over the wound (n = 14 live); and donut, a silicone cover containing a 2-mm central hole was sutured over the wound (n = 6 live). Fetuses were returned to the uterus and harvested by cesarean section 72 hr postoperatively. Fetal (covered) wounds excluded from amniotic fluid contracted and reepithelialized up to confluence. Sixteen of 19 uncovered wounds expanded, 3 were unchanged; minimal reepithelialization was present in all wounds. Partially (donut) covered wounds exhibited an intermediate response. This study shows that excisional wounds in the rabbit fetus respond to injury by contracting and reepithelializing when excluded from amniotic fluid.
M S Ledbetter; M J Morykwas; J A Ditesheim; W D Vander Ark; J R La Rosee; L C Argenta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  27     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-18     Completed Date:  1991-12-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Department of Plastic and Reconstructive Surgery, Bowman Gray School of Medicine, Wake Forest University Medical Center, Winston-Salem, NC 27103.
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MeSH Terms
Amniotic Fluid / physiology*
Fetal Diseases / pathology,  surgery
Fetus / surgery*
Wound Healing*
Wounds and Injuries / pathology,  surgery

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