| The effects of partial and total amniotic fluid exclusion on excisional fetal rabbit wounds. | |
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MedLine Citation:
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PMID: 1952737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have consistently demonstrated that fetal rabbit excisional wounds exposed to amniotic fluid do not heal in utero. This study examines fetal wounds covered to exclude amniotic fluid. Full-thickness excisional wounds were created on fetal rabbits on day 25 of gestation. The following three treatment groups were examined: uncovered (n = 19 live); covered, a silicone cover was sutured over the wound (n = 14 live); and donut, a silicone cover containing a 2-mm central hole was sutured over the wound (n = 6 live). Fetuses were returned to the uterus and harvested by cesarean section 72 hr postoperatively. Fetal (covered) wounds excluded from amniotic fluid contracted and reepithelialized up to confluence. Sixteen of 19 uncovered wounds expanded, 3 were unchanged; minimal reepithelialization was present in all wounds. Partially (donut) covered wounds exhibited an intermediate response. This study shows that excisional wounds in the rabbit fetus respond to injury by contracting and reepithelializing when excluded from amniotic fluid. |
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Authors:
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M S Ledbetter; M J Morykwas; J A Ditesheim; W D Vander Ark; J R La Rosee; L C Argenta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of plastic surgery Volume: 27 ISSN: 0148-7043 ISO Abbreviation: Ann Plast Surg Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-12-18 Completed Date: 1991-12-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7805336 Medline TA: Ann Plast Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Bowman Gray School of Medicine, Wake Forest University Medical Center, Winston-Salem, NC 27103. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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physiology* Animals Fetal Diseases / pathology, surgery Fetus / surgery* Rabbits Wound Healing* Wounds and Injuries / pathology, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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