Document Detail


The effects of parathyroid hormone applied at different regimes on the trochanteric region of the femur in ovariectomized rat model of osteoporosis.
MedLine Citation:
PMID:  21603135     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
This study aims to investigate the effects of two application frequencies of parathyroid hormone on the trochanteric region of rat femur. Forty-three-month-old female Sprague-Dawley rats were divided into 4 groups (n = 10/group). Three groups were ovariectomized, and 8 weeks later they were administered the following treatments (5 weeks): soy-free diet (OVX), subcutaneously injected PTH (0.040 mg/kg) 5 days a week (PTH 5x/w), subcutaneously injected PTH (0.040 mg/kg) every 2 days (PTH e2d), and a sham group. The values of the biomechanical and histomorphometric parameters showed higher results in 5x/w animals in comparison to the OVX and PTH 2ed groups. The ratio between bone diameter/marrow diameter (B.Dm/Ma.Dm) in subtrochanteric cross sections did not show any significant differences between PTH 5x/w and PTH e2d. The increased bone formation rate was observed under PTH treatment in both groups mainly at the endosteal side. The endosteum seems here to be one of the targets of PTH with an accelerate bone formation and a pronounced filling-in of intracortical cavities with higher intensity for the PTH 5x/w in comparison to PTH e2d rats.
Authors:
M Tezval; A Banhardt; S Sehmisch; L Kolios; U Schmelz; K M Stuermer; E K Stuermer
Related Documents :
18435835 - Evaluation of behavioural and antioxidant activity of cytisus scoparius link in rats ex...
3452275 - Effect of antidepressant on behavior and central catecholamine of depression-model rats.
10073475 - Unilateral block of nmda receptors in the amygdala prevents predator stress-induced las...
22196585 - Effect of emex spinosa, leptadenia pyrotechnica, haloxylon salicornicum and ochradenus ...
7175105 - Effects of the interaction of the ovary with an androstane nitrile on the uterus of the...
24260535 - Going with the flow: detection of drift in response to hypo-saline stress by the estuar...
Publication Detail:
Type:  Journal Article     Date:  2011-04-13
Journal Detail:
Title:  Journal of osteoporosis     Volume:  2011     ISSN:  2042-0064     ISO Abbreviation:  J Osteoporos     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-07-14     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  101538878     Medline TA:  J Osteoporos     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363617     Citation Subset:  -    
Affiliation:
Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, 37075 Goettingen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute arterial thrombosis after covered stent exclusion of bleeding mycotic pseudoaneurysm: treatmen...
Next Document:  Testosterone increases: sodium reabsorption, blood pressure, and renal pathology in female spontaneo...