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The effects of parathyroid hormone applied at different regimes on the trochanteric region of the femur in ovariectomized rat model of osteoporosis.
MedLine Citation:
PMID:  21603135     Owner:  NLM     Status:  PubMed-not-MEDLINE    
This study aims to investigate the effects of two application frequencies of parathyroid hormone on the trochanteric region of rat femur. Forty-three-month-old female Sprague-Dawley rats were divided into 4 groups (n = 10/group). Three groups were ovariectomized, and 8 weeks later they were administered the following treatments (5 weeks): soy-free diet (OVX), subcutaneously injected PTH (0.040 mg/kg) 5 days a week (PTH 5x/w), subcutaneously injected PTH (0.040 mg/kg) every 2 days (PTH e2d), and a sham group. The values of the biomechanical and histomorphometric parameters showed higher results in 5x/w animals in comparison to the OVX and PTH 2ed groups. The ratio between bone diameter/marrow diameter (B.Dm/Ma.Dm) in subtrochanteric cross sections did not show any significant differences between PTH 5x/w and PTH e2d. The increased bone formation rate was observed under PTH treatment in both groups mainly at the endosteal side. The endosteum seems here to be one of the targets of PTH with an accelerate bone formation and a pronounced filling-in of intracortical cavities with higher intensity for the PTH 5x/w in comparison to PTH e2d rats.
M Tezval; A Banhardt; S Sehmisch; L Kolios; U Schmelz; K M Stuermer; E K Stuermer
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Publication Detail:
Type:  Journal Article     Date:  2011-04-13
Journal Detail:
Title:  Journal of osteoporosis     Volume:  2011     ISSN:  2042-0064     ISO Abbreviation:  J Osteoporos     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-07-14     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  101538878     Medline TA:  J Osteoporos     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363617     Citation Subset:  -    
Department of Trauma and Reconstructive Surgery, Georg-August-University of Goettingen, 37075 Goettingen, Germany.
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