Document Detail

The effects of paraquat on cultured human embryonic cells.
MedLine Citation:
PMID:  501763     Owner:  NLM     Status:  MEDLINE    
The effects of paraquat on human embryonic somatic cells were studied. Monolayer cultured cells, from several different organs, were exposed to various concentrations of paraquat. Then, the cells were stained with nigrosine and Sudan IV to demonstrate dead or damaged cells and fatty granules, respectively. The lowest paraquat concentration that caused morphological changes varied from 1 to 10 ppm, and the lowest concentration that caused fatty degeneration varied from 1 to 5 ppm. In both types of staining, the lowest degenerative concentration was lower as the culture generation was younger, and the degree of degeneration did not differ with the cell origin. The protein content per cell in paraquat-treated cells was not significantly decreased in comparison with control cells.
E Kurisaki; H Sato; H Nagamori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  4     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1979 May 
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Embryo, Mammalian / drug effects*
Paraquat / metabolism,  toxicity*
Proteins / metabolism
Reg. No./Substance:
0/Proteins; 4685-14-7/Paraquat

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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