Document Detail

The effects of pacing-induced left bundle branch block on left ventricular systolic and diastolic performances.
MedLine Citation:
PMID:  2214133     Owner:  NLM     Status:  MEDLINE    
To assess the effects of pacing-induced left bundle branch block on left ventricular (LV) systolic and diastolic performance, we performed digital subtraction ventriculography while simultaneously measuring LV pressure with a catheter tip micromanometer. The subjects included 10 patients with a sinus rhythm, a normal QRS duration and PR interval within 0.22 sec. LV performance was assessed during both right atrial pacing (AP) and atrioventricular sequential pacing (AVP) at the same pacing rate. The atrioventricular pacing interval during AVP was adjusted to be the maximal interval that showed the QRS configuration seen during complete right ventricular pacing. LV end-diastolic pressure and volume during AVP did not differ from those during AP. Peak positive and negative dp/dt during AVP were significantly lower than those during AP. Time constants were also significantly longer during AVP. The QRS duration during AVP significantly correlated with end-systolic volume and time constants, and inversely correlated with ejection fraction and +dp/dt. These observations indicated that conduction disturbance per se, induced by AVP, could not only impair LV systolic performance but also diastolic performance, possibly due to asynchronous contraction and relaxation of the left ventricle.
A Tanabe; T Mohri; M Ohga; O Yoshiga; Y Hidaka; H Ikeda; K Hiyamuta; Y Koga; H Toshima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese heart journal     Volume:  31     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-11-02     Completed Date:  1990-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  309-17     Citation Subset:  IM    
Third Department of Internal Medicine, Kurume University School of Medicine, Japan.
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MeSH Terms
Blood Pressure
Bundle-Branch Block / etiology,  physiopathology*
Cardiac Pacing, Artificial* / methods
Heart Conduction System / physiopathology
Heart Ventricles / physiopathology,  radiography
Middle Aged
Stroke Volume
Ventricular Function, Left*

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