Document Detail

The effects of p-chlorophenylalanine and ethanolamine-O-sulphate in an animal test of anxiety.
MedLine Citation:
PMID:  22619     Owner:  NLM     Status:  MEDLINE    
p-Chlorophenylalanine, which produces a depletion of brain 5-HT concentration, had effects qualitatively similar to those previously found with chronic chlordiazepoxide and with acute ethanol in the social interaction test of anxiety. This result is compatible with the idea that a reduced turnover of 5-HT is important in anxiety reduction. On the same test, ethanolamine-O-sulphate, which raises brain gamma-aminobutyric acid, was without effect, suggesting raised concentrations of this acid are not essential for anxiety reduction.
S E File; J R Hyde
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  29     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  735-8     Citation Subset:  IM    
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MeSH Terms
Anxiety / metabolism,  psychology*
Brain Chemistry / drug effects
Ethanolamines / pharmacology*
Fenclonine / pharmacology*
Motor Activity / drug effects
Serotonin / metabolism
Social Behavior / drug effects
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Ethanolamines; 50-67-9/Serotonin; 56-12-2/gamma-Aminobutyric Acid; 7424-00-2/Fenclonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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