Document Detail

The effects of oxidative stress on outcomes of assisted reproductive techniques.
MedLine Citation:
PMID:  16391897     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the impact of oxidative stress on pregnancy success by monitoring malondialdehyde levels in follicular fluid.
METHODS: Forty five couples were enrolled in this prospective study. Following long protocol of GnRH analogues and r-FSH treatment, oocyte retrieval and intracytoplasmic sperm injection were performed. Malondialdehyde levels were assayed by thiobarbutiric acid reacting substances test. Student's t-test and chi(2) test were used for statistical analysis.
RESULTS: Patients were divided into two groups; group I (pregnancy positive, n = 20), group II (pregnancy negative, n = 25). There was no statistical significant difference in terms of age, infertility period, FSH levels on the third day, number of oocytes retrieved and fertilization rates between the two groups. Pregnancy rates were found to be decreasing in higher malondialdehyde levels.
CONCLUSION: Malondialdehyde can be used as a marker of oxidative stress and a potential marker in predicting assisted reproductive techniques outcome.
Ozay Oral; Tayfun Kutlu; Evrim Aksoy; Cem Fiçicioğlu; Hüsamettin Uslu; Semih Tuğrul
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Publication Detail:
Type:  Journal Article     Date:  2006-01-04
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  23     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2007-01-04     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Zeynep Kamil Training and Research Hospital, Assisted Reproductive Techniques Department, Istanbul, Turkey.
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MeSH Terms
Follicular Fluid / metabolism
Malondialdehyde / metabolism
Oxidative Stress / physiology*
Pregnancy Outcome*
Reproductive Techniques, Assisted*
Reg. No./Substance:

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