| The effects of orally administered atenolol on the coronary hemodynamics and prostaglandin metabolism in angina pectoris patients. | |
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MedLine Citation:
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PMID: 8129203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of oral atenolol on coronary hemodynamics and prostaglandin metabolism have been investigated in 8 chronic stable angina pectoris patients who underwent the supine bicycle ergometer. At rest, atenolol taken orally reduced the pressure-rate product significantly (P < 0.05) but did not significantly affect the coronary sinus blood flow or the coronary sinus pressure. During exercise, atenolol also reduced the pressure-rate product significantly (P < 0.05) but did not significantly affect the coronary sinus blood flow, the coronary sinus pressure, or the coronary vascular resistance. Atenolol also did not significantly affect the thromboxane B2/6-keto prostaglandin F1 alpha ratio in the arterial blood before and after exercise but did reduce this ratio in the coronary sinus blood by 15% from 1.9 +/- 1.1 to 1.5 +/- 0.46 (P < 0.10) after exercise. These results indicate that atenolol taken orally does not significantly depress the coronary hemodynamics. However, the effects of atenolol on the prostaglandin metabolism could not be clearly determined. |
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Authors:
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A Kurita; B Takase; A Uehata; T Nishioka; K Satomura; H Nagayoshi; K Mizuno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Angiology Volume: 45 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-04-11 Completed Date: 1994-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 219-24 Citation Subset: IM |
Affiliation:
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1st Department of Internal Medicine, National Defense Medical College, Saitama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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blood Administration, Oral Adult Aged Angina Pectoris / drug therapy*, metabolism, physiopathology Atenolol / administration & dosage, pharmacology, therapeutic use* Blood Pressure / drug effects Exercise Test Heart / drug effects*, physiopathology Heart Rate / drug effects Hemodynamics / drug effects* Humans Lactates / blood Male Middle Aged Prostaglandins / metabolism* Regional Blood Flow / drug effects Thromboxane B2 / blood Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Prostaglandins; 29122-68-7/Atenolol; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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