Document Detail


The effects of orally administered atenolol on the coronary hemodynamics and prostaglandin metabolism in angina pectoris patients.
MedLine Citation:
PMID:  8129203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of oral atenolol on coronary hemodynamics and prostaglandin metabolism have been investigated in 8 chronic stable angina pectoris patients who underwent the supine bicycle ergometer. At rest, atenolol taken orally reduced the pressure-rate product significantly (P < 0.05) but did not significantly affect the coronary sinus blood flow or the coronary sinus pressure. During exercise, atenolol also reduced the pressure-rate product significantly (P < 0.05) but did not significantly affect the coronary sinus blood flow, the coronary sinus pressure, or the coronary vascular resistance. Atenolol also did not significantly affect the thromboxane B2/6-keto prostaglandin F1 alpha ratio in the arterial blood before and after exercise but did reduce this ratio in the coronary sinus blood by 15% from 1.9 +/- 1.1 to 1.5 +/- 0.46 (P < 0.10) after exercise. These results indicate that atenolol taken orally does not significantly depress the coronary hemodynamics. However, the effects of atenolol on the prostaglandin metabolism could not be clearly determined.
Authors:
A Kurita; B Takase; A Uehata; T Nishioka; K Satomura; H Nagayoshi; K Mizuno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  45     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-11     Completed Date:  1994-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Affiliation:
1st Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
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MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / blood
Administration, Oral
Adult
Aged
Angina Pectoris / drug therapy*,  metabolism,  physiopathology
Atenolol / administration & dosage,  pharmacology,  therapeutic use*
Blood Pressure / drug effects
Exercise Test
Heart / drug effects*,  physiopathology
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Lactates / blood
Male
Middle Aged
Prostaglandins / metabolism*
Regional Blood Flow / drug effects
Thromboxane B2 / blood
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Lactates; 0/Prostaglandins; 29122-68-7/Atenolol; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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