Document Detail

The effects of orally administered atenolol on the coronary hemodynamics and prostaglandin metabolism in angina pectoris patients.
MedLine Citation:
PMID:  8129203     Owner:  NLM     Status:  MEDLINE    
The effects of oral atenolol on coronary hemodynamics and prostaglandin metabolism have been investigated in 8 chronic stable angina pectoris patients who underwent the supine bicycle ergometer. At rest, atenolol taken orally reduced the pressure-rate product significantly (P < 0.05) but did not significantly affect the coronary sinus blood flow or the coronary sinus pressure. During exercise, atenolol also reduced the pressure-rate product significantly (P < 0.05) but did not significantly affect the coronary sinus blood flow, the coronary sinus pressure, or the coronary vascular resistance. Atenolol also did not significantly affect the thromboxane B2/6-keto prostaglandin F1 alpha ratio in the arterial blood before and after exercise but did reduce this ratio in the coronary sinus blood by 15% from 1.9 +/- 1.1 to 1.5 +/- 0.46 (P < 0.10) after exercise. These results indicate that atenolol taken orally does not significantly depress the coronary hemodynamics. However, the effects of atenolol on the prostaglandin metabolism could not be clearly determined.
A Kurita; B Takase; A Uehata; T Nishioka; K Satomura; H Nagayoshi; K Mizuno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  45     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-11     Completed Date:  1994-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
1st Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / blood
Administration, Oral
Angina Pectoris / drug therapy*,  metabolism,  physiopathology
Atenolol / administration & dosage,  pharmacology,  therapeutic use*
Blood Pressure / drug effects
Exercise Test
Heart / drug effects*,  physiopathology
Heart Rate / drug effects
Hemodynamics / drug effects*
Lactates / blood
Middle Aged
Prostaglandins / metabolism*
Regional Blood Flow / drug effects
Thromboxane B2 / blood
Vascular Resistance / drug effects
Reg. No./Substance:
0/Lactates; 0/Prostaglandins; 29122-68-7/Atenolol; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

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