| The effects of oral hydralazine on right ventricular end-diastolic pressure in patients with right ventricular failure. | |
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MedLine Citation:
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PMID: 7074795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydralazine reduces pulmonary vascular resistance in patients with primary and secondary pulmonary hypertension, but the effects on right ventricular function of a change in resistance without a reduction in pulmonary arterial pressure are not known. We evaluated the hemodynamic effects of hydralazine, 50 mg, administered orally every 6 hours for 48 hours in 14 patients with right ventricular failure and pulmonary hypertension resulting from various causes. Hydralazine reduced mean right ventricular end-diastolic pressure from 17.4 +/- 5.6 to 11.6 +/- 5.3 mm Hg (p less than 0.001) and increased cardiac output and stroke volume by more than 40%. In nine patients who had no change in mean pulmonary arterial pressure after hydralazine, total pulmonary resistance decreased from 15.9 +/- 6.0 to 10.6 +/- 4.3 (p less than 0.001) and cardiac index increased from 2.07 +/- 0.51 to 2.97 +/- 0.91 (p less than 0.005). There was a close correlation between the reductions in total pulmonary resistance and right ventricular end-diastolic pressure (r = 0.73)). These data suggest that hydralazine can increase cardiac output and reduce right ventricular end-diastolic pressure even when pulmonary arterial pressure remains unchanged. |
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Authors:
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L J Rubin; F Handel; R H Peter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 65 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1982 Jun |
Date Detail:
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Created Date: 1982-07-22 Completed Date: 1982-07-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1369-73 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arterioles / drug effects Blood Pressure / drug effects* Cardiac Output / drug effects Female Heart Failure / drug therapy* Humans Hydralazine / therapeutic use* Hypertension, Pulmonary / drug therapy* Lung / blood supply Male Middle Aged Stroke Volume / drug effects Vascular Resistance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-0719/HL/NHLBI NIH HHS; RR-30/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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