Document Detail


The effects of oral hydralazine on blood pressure, cardiac output and peripheral resistance with respect to dose, age and acetylator status.
MedLine Citation:
PMID:  2244017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular responses are reported in 21 patients with carcinoma of the bronchus taking part in a study of tumour perfusion. There were eight slow and 12 fast acetylators; acetylator status was not determined in one patient with a history of sulphonamide allergy. Hydralazine dose ranged from 25 to 150 mg orally (equivalent to 0.37 to 2.86 mg/kg). Mean arterial blood pressure fell from 98 mmHg before hydralazine to 90 mmHg 60 min after hydralazine (p = 0.002) and mean cardiac output rose from 5.53 l/min to 7.75 l/min (p = 0.00005). Calculated total peripheral resistance fell by 30% (p = 0.0002). Falls in peripheral resistance per milligram hydralazine administered were greater in patients over 70 years of age. Acetylator status was a poor predictor of response. Side-effects were reported by eight patients and were related to the magnitude of fall in peripheral resistance (p = 0.0005) but not to falls in blood pressure (p = 0.12).
Authors:
N P Rowell; K Clark
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  18     ISSN:  0167-8140     ISO Abbreviation:  Radiother Oncol     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1991-01-02     Completed Date:  1991-01-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Affiliation:
Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey, U.K.
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Administration, Oral
Age Factors
Aged
Blood Pressure / drug effects*
Carcinoma, Bronchogenic / drug therapy,  physiopathology*
Cardiac Output / drug effects*
Dose-Response Relationship, Drug
Female
Humans
Hydralazine / administration & dosage,  pharmacology*
Lung Neoplasms / drug therapy,  physiopathology*
Male
Middle Aged
Vascular Resistance / drug effects*
Chemical
Reg. No./Substance:
86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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