Document Detail


The effects on offspring of premature parturition.
MedLine Citation:
PMID:  11556496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The time of parturition defines the length of the intrauterine period of fetal life, a requisite to achieve adequate adaptation to the external environment. Immaturity, a condition whose severity is inversely related to the length of pregnancy, is the main determinant of the increased morbidity and mortality associated with preterm birth. Despite great advances in medical technology and expertise, mainly after the introduction of the neonatal intensive care units, only one- to two-thirds of infants from the subsets with lower birthweight/gestational age reach survival at discharge. Distinct major neurological and sensorial sequelae, including cerebral palsy, retinopathy of prematurity, and hearing loss, as well as reduced neuropsychological abilities, leading to deficient academic achievement and deterioration of several aspects of health status, are still highly prevalent among the most immature children. Interestingly, decreasing mortality rates, which are not followed by detectable increases of disability, are being observed in recent years. Future advances may be expected from clinical and basic research on uterine contractility and cervical softening. Also, changes in reproductive technology procedures, a main factor in the incidence of multiple pregnancies, and a more refined approach to obstetric care, compose some of the clinical interventions which may reduce the problem.
Authors:
A Cano; F Fons; J Brines
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  7     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2001-09-14     Completed Date:  2002-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  487-94     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Obstetrics and Gynaecology, University of Valencia, Spain. antonio.cano@uv.es
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MeSH Terms
Descriptor/Qualifier:
Developed Countries
Disabled Persons
Female
Fetus / physiology*
Humans
Infant Mortality
Infant, Newborn
Infant, Premature / physiology
Obstetric Labor, Premature / epidemiology,  physiopathology*
Pregnancy
Prevalence
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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