| The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects. | |
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MedLine Citation:
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PMID: 17369807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this work was to determine the ergogenic effects of a nucleotide supplement on the metabolic and immune responses to short term high intensity exercise in volunteer, trained, male subjects. METHODS: Thirty moderately trained male subjects were randomly divided into 3 equal sized groups, control (C), placebo (P) or experimental (E). Each subject undertook a 2 min maximal exercise test prior to, and after 60 days, on either a nucleotide (E) or placebo supplement. Prior to exercise testing unstimulated saliva samples and blood samples were taken. Saliva was analysed for cortisol and IgA, while blood was analysed for lactate, lactate dehydrogenase and creatine kinase. RESULTS: The postexercise C value was significantly higher than the pre-exercise concentration (P<0.0001; for C, P, and E). In the postsupplement C analysis, the E postexercise group was significantly lower than either the C (P<0.005) or the P group (P<0.05). In the pre- and postsupplementation periods, the pre-exercise SIgA values were significantly higher than the postexercise values (P<0.0001). However, in the postsupplementation period, the SIgA value in the E group was significantly higher than either the P (P<0.05) or C (P<0.05) groups. There were no significant changes in blood lactate, lactate dehydrogenase, or creatine kinase concentrations post supplementation. CONCLUSIONS: We concluded that a chronically ingested nucleotide supplement blunts the response of the hormones associated with physiological stress. |
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Authors:
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L Mc Naughton; D Bentley; P Koeppel |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of sports medicine and physical fitness Volume: 47 ISSN: 0022-4707 ISO Abbreviation: J Sports Med Phys Fitness Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-06-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376337 Medline TA: J Sports Med Phys Fitness Country: Italy |
Other Details:
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Languages: eng Pagination: 112-8 Citation Subset: IM |
Affiliation:
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Department of Sport Science, University of Hull, Hull, UK. l.mcnaughton@hull.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Creatine Kinase / blood Dietary Supplements* Exercise Test Humans Hydrocortisone / analysis Immunoglobulin A / analysis Lactates / blood Male Nucleotides / administration & dosage* Physical Endurance / drug effects* Saliva / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Lactates; 0/Nucleotides; 50-23-7/Hydrocortisone; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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