Document Detail


The effects of nortriptyline and mesoridazine on neurons and glia in vitro.
MedLine Citation:
PMID:  197213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ultrastructural changes produced by Mesoridazine and Nortriptyline in neurons and glia in vitro are reported. Concentrically laminated bodies (CLB) and increased numbers of dense bodies were produced by exposure to these drugs. The number and complexity of the CLB increased with increased dose and longer time in vitro and their formation appeared to be reversible.
Authors:
M L Grunnet
Related Documents :
2660633 - Asthma in the pregnant patient: a review.
6493653 - Drug overdose during pregnancy: an overview from a metropolitan poison control center.
7755073 - Timing of conception and the risk of spontaneous abortion among pregnancies occurring d...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  36     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:    1977 Sep-Oct
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  835-41     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Inclusion Bodies / ultrastructure
Mesoridazine / pharmacology*
Mice
Myelin Sheath / drug effects,  ultrastructure
Neuroglia / drug effects*
Neurons / drug effects*,  ultrastructure
Nortriptyline / pharmacology*
Chemical
Reg. No./Substance:
5588-33-0/Mesoridazine; 72-69-5/Nortriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mannosidosis: pathology of the nervous system.
Next Document:  Evidence for dopamine-storing interneurons and paraneurons in rhesus monkey sympathetic ganglia.