Document Detail

The effects of nortriptyline and mesoridazine on neurons and glia in vitro.
MedLine Citation:
PMID:  197213     Owner:  NLM     Status:  MEDLINE    
The ultrastructural changes produced by Mesoridazine and Nortriptyline in neurons and glia in vitro are reported. Concentrically laminated bodies (CLB) and increased numbers of dense bodies were produced by exposure to these drugs. The number and complexity of the CLB increased with increased dose and longer time in vitro and their formation appeared to be reversible.
M L Grunnet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  36     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:    1977 Sep-Oct
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  835-41     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Inclusion Bodies / ultrastructure
Mesoridazine / pharmacology*
Myelin Sheath / drug effects,  ultrastructure
Neuroglia / drug effects*
Neurons / drug effects*,  ultrastructure
Nortriptyline / pharmacology*
Reg. No./Substance:
5588-33-0/Mesoridazine; 72-69-5/Nortriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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