Document Detail


The effects of a normal protein diet on levodopa plasma kinetics in advanced Parkinson's disease.
MedLine Citation:
PMID:  15036167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
LevoDOPA given orally may compete with the neutral aminoacids contained in food for its absorption in the small intestine. LevoDOPA plasma kinetics of the morning intake with 'french' breakfast (low protein content) were compared with those of the noon intake with lunch (normal protein content) in 20 advanced parkinsonian patients (mean disease duration: 10 years). The galenic form and the dosage of levoDOPA were strictly the same for morning and noon intakes in each patient. Blood samplings were collected at T0 (just before intake) and successively at 15, 30, 45, 60, 90, 120, 150 and 180 min after intake. LevoDOPA plasma levels were further measured with HPLC method, then giving the following variables: Cmax (peak concentration), Tmax (time corresponding to Cmax), AUC (area under curve). The results showed no significant difference for Cmax and Tmax whereas the AUC was significantly (P < 0.001) increased for the noon intake, due to the trough concentration effect. These data suggest that, since rich protein diet has been shown to impair the clinical effect of LevoDOPA, this protein effect is probably not due to competitive intestinal absorption of LevoDOPA.
Authors:
Nicolas Simon; Radka Gantcheva; Bernard Bruguerolle; François Viallet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  10     ISSN:  1353-8020     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-04-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie-Faculté de Médecine, 13005 Marseille, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Area Under Curve
Dietary Proteins / blood*
Female
Food-Drug Interactions / physiology*
Humans
Levodopa / blood*,  therapeutic use
Male
Middle Aged
Parkinson Disease / blood*,  drug therapy*
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Dietary Proteins; 0/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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