Document Detail

The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat.
MedLine Citation:
PMID:  8875718     Owner:  NLM     Status:  MEDLINE    
STUDY DESIGN: This was a prospective study to determine the potential effects of indomethacin on spinal fusions in the rat. OBJECTIVES: To determine if indomethacin exerts a deleterious effect on spinal fusions in the rat model. SUMMARY OF BACKGROUND DATA: Nonsteroidal anti-inflammatory drugs are a class of compound that affect bone osteogenesis during fracture healing and heterotopic ossification. Spinal fusion is a process that occurs via osteogenesis and, therefore, may be similarly affected. METHODS: Thirty-nine adult, Sprague-Dawley rats underwent a three-level posterior spinal fusion. Fusion was performed using morselized autogenous vertebral bone graft obtained via caudectomy and stabilized using a cerclage wiring technique. The 39 rats were divided into two groups consisting of 17 study animals and 22 control animals. The control group was injected with 1.5 cc of 0.9 normal saline subcutaneously for 12 weeks, whereas the test animals were injected on an identical schedule using 3 mg/kg of indomethacin sodium salt. Two control animals died, and three animals in the treatment group died of drug-related complications. Twelve weeks after surgery, all animals were killed, and the involved spinal segments were evaluated by direct manual examination. A fusion was probable if the spinal segments exhibited decreased scaled micromotion. RESULTS: Sixty segmental levels in 20 control animals were assessed. Overall, 27 of 60 levels (45%) achieved fusion. In the indomethacin-treated group, 42 levels in 14 animals were evaluated. Overall, four of 42 levels (10%) achieved a fusion. Chi-square analysis demonstrated a significant difference (P < 0.001) between the control and indomethacin-treated groups. CONCLUSIONS: This study raises serious questions about the inhibitory effects of nonsteroidal anti-inflammatory drugs on spinal fusion. Clinically, the widespread use of nonsteroidal anti-inflammatory drugs in the postoperative period after spinal fusion may need to be avoided.
J R Dimar; W A Ante; Y P Zhang; S D Glassman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Spine     Volume:  21     ISSN:  0362-2436     ISO Abbreviation:  Spine     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2009-07-09    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1870-6     Citation Subset:  IM    
Department of Orthopaedic Surgery, University of Louisville School of Medicine, Kentucky, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects*
Indomethacin / administration & dosage,  adverse effects*
Injections, Subcutaneous
Laminectomy / contraindications*
Lumbar Vertebrae / radiography,  surgery*
Osteogenesis / drug effects
Rats, Sprague-Dawley
Survival Rate
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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