| The effects of nitrous acid on the mutagenicity of two coal liquids and their genetically active chemical fractions. | |
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MedLine Citation:
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PMID: 7038455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Ames/Salmonella assay was used to determine the effect of nitrous acid on the mutagenicity of solvent refined coal (SRC) distillates and distillate fractions. The SRC materials consisted of the higher-molecular-weight, high-boiling distillates, the process solvent (PS) and heavy distillate (HD), and also included the basic tar and neutral tar chemical fractions derived from these 2 distillates. Nitrosation products of each of the SRC materials were less mutagenic than the distillates of distillate fractions from which they were derived (untreated materials); in most cases they were less than 10% as mutagenic as that observed in the starting materials. The mutagenicity of the SRC materials after nitrous acid treatment was direct-acting, whereas all mutagenicity associated with the untreated SRC materials was indirect and required metabolic activation for expression in the Ames assay system. |
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Authors:
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R A Pelroy; D L Stewart |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Mutation research Volume: 90 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-05-12 Completed Date: 1982-05-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 297-308 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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pharmacology* Coal* Mutagenicity Tests Mutagens / pharmacology* Mutation* Nitrous Acid Salmonella typhimurium / drug effects Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Coal; 0/Mutagens; 7782-77-6/Nitrous Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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