Document Detail

The effects of nitrous acid on the mutagenicity of two coal liquids and their genetically active chemical fractions.
MedLine Citation:
PMID:  7038455     Owner:  NLM     Status:  MEDLINE    
The Ames/Salmonella assay was used to determine the effect of nitrous acid on the mutagenicity of solvent refined coal (SRC) distillates and distillate fractions. The SRC materials consisted of the higher-molecular-weight, high-boiling distillates, the process solvent (PS) and heavy distillate (HD), and also included the basic tar and neutral tar chemical fractions derived from these 2 distillates. Nitrosation products of each of the SRC materials were less mutagenic than the distillates of distillate fractions from which they were derived (untreated materials); in most cases they were less than 10% as mutagenic as that observed in the starting materials. The mutagenicity of the SRC materials after nitrous acid treatment was direct-acting, whereas all mutagenicity associated with the untreated SRC materials was indirect and required metabolic activation for expression in the Ames assay system.
R A Pelroy; D L Stewart
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  90     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  297-308     Citation Subset:  IM    
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MeSH Terms
Amines / pharmacology*
Mutagenicity Tests
Mutagens / pharmacology*
Nitrous Acid
Salmonella typhimurium / drug effects
Structure-Activity Relationship
Reg. No./Substance:
0/Amines; 0/Coal; 0/Mutagens; 7782-77-6/Nitrous Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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