| The effects of nicotine on the metabolic and hormonal responses during acute cold exposure. | |
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MedLine Citation:
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PMID: 17078309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the effects of nicotine on the metabolic and hormonal responses during acute cold exposure. METHODS: Participants in this study included 6 men and 5 women between the ages of 19 and 25 years. Each subject performed 2 cold-air trials (CATs) consisting of a 30-minute baseline (BASE) period and a 120-minute exposure to 10 degree C air. One CAT was performed after a nicotine (NIC) dosing using a 21-mg transdermal patch, whereas the other CAT was performed after a placebo (PL) treatment. Blood samples for metabolic and hormonal measurements were obtained at the end of BASE and immediately after the cold exposure. RESULTS: When examining the sexes separately, there was no difference in norepinephrine between PL and NIC (P = .066). There was also no difference in epinephrine between PL and NIC in either sex (P = .634). From BASE to 120 minutes of the CAT, there was a significant decrease in cortisol (P = .036), but this response was similar between the 2 treatments (P = .077). Glucose and glycerol concentrations were not different between the PL and NIC treatments. At BASE, nonesterified fatty acid (NEFA) concentration was lower during PL compared with NIC (P = .021); however, at 120 minutes of the CAT, NEFA was greater during PL compared with NIC (P = .035). CONCLUSIONS: During 120 minutes of cold exposure, NIC resulted in alterations in the responses in NEFA, whereas the other blood measurements were not significantly different between the 2 groups. |
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Authors:
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Christopher C Cheatham; Natalie Caine-Bish; Mark Blegen; Edward S Potkanowicz; Gary H Kamimori; Jennifer L Marcinkiewicz; Ronald Otterstetter; Michael Kalinski; Ellen L Glickman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Wilderness & environmental medicine Volume: 17 ISSN: 1080-6032 ISO Abbreviation: Wilderness Environ Med Publication Date: 2006 |
Date Detail:
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Created Date: 2006-11-02 Completed Date: 2006-11-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9505185 Medline TA: Wilderness Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 147-57 Citation Subset: IM |
Affiliation:
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Department of Health, Physical Education, and Recreation, Western Michigan University, 1903 W Michigan Ave, Kalamazoo, MI 49008, USA. chris.cheatham@wmich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Area Under Curve Blood Glucose / analysis Body Temperature Regulation / physiology Cold Temperature* Cross-Over Studies Fatty Acids, Nonesterified / blood* Female Glycerol / blood Hormones / blood* Humans Hydrocortisone / blood Male Nicotine / pharmacology* Norepinephrine / blood Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Hormones; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 54-11-5/Nicotine; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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