Document Detail


The effects of nicotine on cell division of HeLa cells.
MedLine Citation:
PMID:  488124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A time lapse cinemicrographic study shows that, at low concentrations, nicotine can speed up cytokinesis and, at high concentrations, prolong the duration of metaphase in HeLa cells. Based upon the known effects of the alkaloid in other systems, it appears that it may stimulate microfilament activity and inhibit microtubule function by increasing the level of cytosolic calcium ions.
Authors:
S S Ved Brat; J E Sisken; R L Anderson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of cell biology     Volume:  19     ISSN:  0171-9335     ISO Abbreviation:  Eur. J. Cell Biol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906240     Medline TA:  Eur J Cell Biol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  250-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Division / drug effects
Hela Cells / drug effects,  physiology*
Humans
Kinetics
Mitosis / drug effects
Nicotine / pharmacology*
Chemical
Reg. No./Substance:
54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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