| The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection. | |
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MedLine Citation:
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PMID: 16967377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Postoperative respiratory failure is often encountered in patients suffering from acute aortic dissection (AAD) and is believed to be influenced by release of neutrophil elastase after cardiopulmonary bypass. Sivelestat is a specific neutrophil elastase inhibitor, and this study aims to evaluate the effects of sivelestat on postoperative respiratory failure due to AAD. METHODS AND RESULTS: Patients who were operated for AAD from January 2000 to April 2005 and who had less than 300 mmHg initial postoperative PaO (2)/FiO (2) were investigated retrospectively and divided into two groups. Group 1 (n = 9) received intravenous administration of sivelestat immediately after the operation, while Group II (n = 9) received no sivelestat. There were no significant differences between Group I and II with respect to patients' characteristics or background (age, body weight, operating time, cardiopulmonary bypass time, amount of bleeding, preoperative WBC number and initial PaO (2)/FiO (2)). Though patients in Group I showed a subtle improvement in certain parameters such as PaO (2)/FiO (2), A-aDO (2) and respiratory index (RI) over a 3-day observation period compared to those of Group II, there were no significant differences. Neither postoperative mechanical ventilation time nor ICU stay differed between Group I and II. However, Group I showed a significantly greater improvement in the ratio of RI to initial RI on the 3POD compared to that of Group II (61.6 +/- 44.2 % vs. 111.9 +/- 40.9 %, P = 0.02). CONCLUSION: Inhibiting the activity of the neutrophil elastase may attenuate the postoperative respiratory complications of patients with AAD. |
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Authors:
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T Furusawa; K Tsukioka; D Fukui; M Sakaguchi; T Seto; T Terasaki; Y Wada; J Amano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Thoracic and cardiovascular surgeon Volume: 54 ISSN: 0171-6425 ISO Abbreviation: Thorac Cardiovasc Surg Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-12 Completed Date: 2007-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903387 Medline TA: Thorac Cardiovasc Surg Country: Germany |
Other Details:
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Languages: eng Pagination: 404-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Division of Cardiovascular Surgery, Shinshu University School of Medicine, Matsumoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Aneurysm, Dissecting / surgery* Aortic Aneurysm / surgery* Cardiopulmonary Bypass / adverse effects Female Glycine / analogs & derivatives*, therapeutic use Humans Male Postoperative Care Proteinase Inhibitory Proteins, Secretory / therapeutic use* Respiratory Insufficiency / prevention & control* Retrospective Studies Serine Proteinase Inhibitors / therapeutic use* Sulfonamides / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Proteinase Inhibitory Proteins, Secretory; 0/Serine Proteinase Inhibitors; 0/Sulfonamides; 127373-66-4/ONO 5046; 56-40-6/Glycine |
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