Document Detail


The effects of neurosurgical stress on peripheral lymphocyte subpopulations.
MedLine Citation:
PMID:  12657403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVE: To observe changes in the peripheral lymphocyte subpopulations as an index of cellular immunity during neurosurgical procedures.
DESIGN: Clinical study.
SETTING: Operating room of a university hospital.
PATIENTS: 11 patients with early intracranial disease who were scheduled to undergo elective neurosurgery with general anesthesia. Patients in the control group (n = 10) underwent minor surgeries such as ophthalmologic, otorhinolaryngological, or orthopedic surgeries.
INTERVENTIONS: Blood was sampled before anesthesia induction (t0) for baseline and at 1 hour (t(1)) and 2 hours (t(2)) following surgical incision.
MEASUREMENTS: Detection and quantification of lymphocyte subpopulations were performed at each time point using single-label and double-label analyses of monoclonal antibodies against lymphocyte membrane surface markers.
MAIN RESULTS: Significant changes in patients who underwent a neurosurgical procedure included: the percentage of total T cells (CD3+) from 57.54 +/- 3.50% at t(0) to 51.41 +/- 4.26% at t(1) and 46.29 +/- 4.02% at t(2); the percentage of inducer T cells (CD4+, Leu8+) from 27.39 +/- 2.26% at t(0), to 23.26 +/- 2.30% at t(1) and 20.82 +/- 2.70% at t(2); the CD4/CD8 ratio, from 1.78 +/- 0.25% at t(0) to 1.35 +/- 0.12% at t(1) and 1.22 +/- 0.17% at t(2). The percentage of suppressor T cells (CD8+, Leu15+) increased significantly from 10.8 +/- 1.07% at t(0) to 13.64 +/- 1.62% at t(1), and 14.82 +/- 1.24% at t(2). The percentages of the natural killer cell subsets also increased significantly. Control group patients who underwent minor surgeries showed no significant changes.
CONCLUSIONS: Neurosurgery-induced significant suppression of cellular immunity was demonstrated in peripheral lymphocyte subpopulations, probably from the surgical stress on the central nervous system.
Authors:
Yoshiyuki Hori; Takae Ibuki; Toyoshi Hosokawa; Yoshifumi Tanaka
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  15     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-07-14     Revised Date:  2012-03-02    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General
Antibodies, Monoclonal
Antigens, CD3 / drug effects
CD4 Lymphocyte Count
CD4-CD8 Ratio
Female
Flow Cytometry
Humans
Immunity, Cellular / immunology
Killer Cells, Natural
Lymphocyte Count
Lymphocytes / immunology,  physiology*
Male
Middle Aged
Neurosurgical Procedures / adverse effects*
Receptors, Cell Surface / drug effects
Stress, Physiological / immunology*
T-Lymphocytes, Regulatory
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD3; 0/Receptors, Cell Surface
Comments/Corrections
Comment In:
J Clin Anesth. 2012 Feb;24(1):1-2   [PMID:  22154093 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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