| The effects of nerve growth factor on spatial recent memory in aged rats persist after discontinuation of treatment. | |
| | |
MedLine Citation:
|
PMID: 9065514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nerve growth factor (NGF) infusion significantly reduces spatial recent memory deficits in aged rats, an effect that has great relevance to the treatment of memory impairments characteristic of patients with Alzheimer's disease. The present study was designed to examine whether this NGF-induced improvement in spatial recent memory persists after the discontinuation of NGF treatment, an issue of crucial importance for the potential clinical use of this compound. Spatial recent memory was tested in a Morris water maze delayed nonmatch-to-position task. In addition to memory, sensorimotor skills were also examined. Four- and 22-month-old rats were tested preoperatively, infused intraventricularly with recombinant human NGF or vehicle, and tested both during the 4 week infusion period and during the 4 weeks after discontinuation of the infusion. NGF significantly improved spatial recent memory in 22-month-old rats only, during the 4th week of infusion and for up to 4 weeks after discontinuation of the infusion. Although NGF did not affect overall sensorimotor skills during infusion in either age group, sensorimotor skills were significantly improved both 2 and 4 weeks after discontinuation of infusion in 22-month-old rats. These findings demonstrate that the beneficial effects of NGF on spatial recent memory can persist for up to 1 month after discontinuation of infusion and suggest that NGF can be used intermittently for the treatment of age-associated memory dysfunction and Alzheimer's disease. |
| | |
Authors:
|
K M Frick; D L Price; V E Koliatsos; A L Markowska |
Related Documents
:
|
3567534 - Physiological and behavioural consequences of seizures induced in the rat by intrahippo... 15671344 - Rats are able to navigate in virtual environments. 8864044 - Contribution of egocentric spatial memory to place navigation of rats in the morris wat... 2350324 - Memory for frequency in rats: role of the hippocampus and medial prefrontal cortex. 12395984 - Mid-basal-to-ceiling versus mid-ceiling-to-basal elicitation of maximum phonational fre... 19653774 - Effects of emotionally contagious films on changes in hemisphere-specific cognitive per... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 17 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1997 Apr |
Date Detail:
|
Created Date: 1999-02-25 Completed Date: 1999-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2543-50 Citation Subset: IM |
Affiliation:
|
Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Animals Body Weight Choice Behavior Escape Reaction Humans Male Maze Learning / drug effects, physiology* Nerve Growth Factors / pharmacology* Orientation Psychomotor Performance / drug effects, physiology Rats Rats, Inbred F344 Recombinant Proteins / pharmacology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
NS 10580/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Nerve Growth Factors; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Failure of centrally placed objects to control the firing fields of hippocampal place cells.
Next Document: An escalating dose "binge" model of amphetamine psychosis: behavioral and neurochemical characterist...