| The effects of nebulized albuterol on esophageal function in asthmatic patients. | |
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MedLine Citation:
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PMID: 18270832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Albuterol reduces lower esophageal sphincter (LES) pressure in normal volunteers, although the effects of albuterol on esophageal function in asthmatic patients are not known. The aim of this study was to evaluate the effects of nebulized albuterol on lower esophageal function in asthmatic patients. Symptoms and a methacholine challenge test were used to identify asthmatic patients who were then enrolled in a prospective, randomized, placebo-controlled, double-blinded, crossover trial. Changes in esophageal function in response to nebulized albuterol or placebo were evaluated over two sessions spaced 1 week apart. RESULTS: Albuterol induced a dose-dependent drop in lower esophageal sphincter basal pressure with a threshold dose as low as 2.5 mg. Albuterol did not affect the amplitude of esophageal contractions. CONCLUSIONS: Nebulized albuterol induces a dose-dependent reduction in LES basal pressure in asthmatic patients. These effects raise the possibility that gastroesophageal reflux may occur after bronchodilator therapy. |
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Authors:
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Brian E Lacy; Carole Mathis; John DesBiens; Mark C Liu |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-02-13 |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 53 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-01 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2627-33 Citation Subset: AIM; IM |
Affiliation:
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Section of Gastroenterology & Hepatology, Dartmouth-Hitchcock Medical Center, Area 4C, 1 Medical Center Drive, Lebanon, NH 03756, USA, brian.lacy@hitchcock.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuterol / adverse effects, pharmacology*, therapeutic use Asthma / drug therapy, physiopathology* Bronchodilator Agents / adverse effects, pharmacology*, therapeutic use Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Esophageal Sphincter, Lower / drug effects*, physiopathology* Female Gastroesophageal Reflux / chemically induced, physiopathology Humans Male Middle Aged Nebulizers and Vaporizers Pressure Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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